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Scientists test new ways to deliver vaccines through nose and mouth

NCT ID NCT00820144

Knowledge-focused Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study in 40 healthy adults explores how the immune system reacts to the non-toxic part of cholera toxin (CTB) when given through the nose, mouth, or under the tongue. The goal is to understand mucosal immune responses, which could help in developing future vaccines that are easier to take. No direct benefit is expected for participants.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cholera toxin B-subunit (CTB)
What this could lead to
If successful, this research could help design better vaccines that are given through the nose or mouth instead of by injection.
What could go wrong
This is a very early, small study with only 40 healthy volunteers. It is not testing a treatment or vaccine, just measuring immune responses, so it may not lead to any practical application.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

40 people

The number who actually took part.

Start date

Apr 2006

Finished

Feb 2007

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult male between 18 and 50 years, * Adult female aged 18 to 50 years under oral contraception (pill) for at least 6 months, or IUD for at least 6 under, and agreeing to carry out a pregnancy test during the initial clinical visit * Affiliate or entitled to Social Security * Signing the informed consent of the volunteer Exclusion Criteria: * Seropositive patient for HIV, Hepatitis B, Hepatitis C (oral questioning) * Pregnant Woman, parturient or breast-feeding * News hospitalized for other reasons that the research * Minor, Major under supervision * Participation in a current or recent study or at present in period of exclusion

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Conditions

The condition(s) this trial relates to.

Infections infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infection

Contacts and locations

Locations

  • Laboratoire d'anatomo-pathologie, hôpital Pasteur

    Nice, 06000, France

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Other studies related to the condition(s) this trial covers.