New cell therapy combo takes on deadly brain cancer
NCT ID NCT00807027
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 3 trial tested whether adding a cell therapy called Immuncell-LC to standard chemotherapy (temozolomide) helps people with newly diagnosed glioblastoma, an aggressive brain cancer. The study enrolled 180 patients in Korea who had surgery for glioblastoma. Researchers measured how long patients lived without the cancer getting worse and overall survival. The goal was to see if the combination is more effective than chemotherapy alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Immuncell-LC (activated T lymphocytes) plus temozolomide
- What this could lead to
- If successful, this combination could improve progression-free survival and overall survival for people with newly diagnosed glioblastoma.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet widely confirmed. Glioblastoma is very aggressive, and even positive findings may offer only modest benefit. Risks include side effects from chemotherapy and the cell therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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180 people
The number who actually took part.
- Started
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Dec 2008
- Finished
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Oct 2012
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Patients who, prior to the study, received explanation of the purpose and content of study and of characteristics of the test drug from the test administrator and have consented to the study by providing signature of self, guardian, or legal representative. 2. Patients who are between 18 and 70 years of age 3. Patients whose cause of cancer has been found to be glioblastoma via pathological testing 4. patients who have received surgery for glioblastoma (Complete or partial extirpation or biopsy) 2 weeks prior to the study 5. Patients whose survival is expected to be longer than 3 months 6. Patients whose KPS is greater than 60 7. Patients who satisfy the following conditions of the blood test, kidney function test, and liver function test * Hemoglobin is bigger than 10 gm% * Platelet Count is bigger than 100,000/µL * Absolute granulocyte count is bigger than 1,500/µL * BUN or Creatinine 1.5 x upper normal limit * Bilirubin level is smaller than 2.0 mg/dL * SGOT, SGPT, alkaline phosphatase is smaller than 1.5 x upper normal limit Exclusion Criteria: 1. Patients who have been determined to have serious Cardio - Pulmonary function disability by the clinical study staff 2. Patients who are immune deficient or have a history of auto immune diseases (Ex. Rheumatoid Arthritis, Systemic Lupus Erythematosus, Vasculitis, Multiple sclerosis, Adolescent Insulin-Dependent Diabetes Mellitus, etc.) 3. Patients who have a history of malignant tumors in the recent 5 years prior to the study with the exception of skin cancer, local prostate cancer, and cervical cancer. 4. Patients with history of severe allergies 5. Patients with serious mental illness 6. Patients who are pregnant or nursing 7. Patients who have participated in other clinical tests in the recent 4 weeks prior to the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Gyunghee University Medical Center
Seoul, South Korea
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Hanyang University Guri Hospital
Guri-si, Gyeonggi-do, South Korea
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Konkuk University
Seoul, South Korea
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Korea University Anam Hospital
Seoul, South Korea
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Samsung Seoul Medical Center
Seoul, South Korea
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Seoul Asan Medical Center
Seoul, South Korea
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Yeonsei University Medical Center
Seoul, South Korea
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