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New cell therapy combo takes on deadly brain cancer

NCT ID NCT00807027

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 trial tested whether adding a cell therapy called Immuncell-LC to standard chemotherapy (temozolomide) helps people with newly diagnosed glioblastoma, an aggressive brain cancer. The study enrolled 180 patients in Korea who had surgery for glioblastoma. Researchers measured how long patients lived without the cancer getting worse and overall survival. The goal was to see if the combination is more effective than chemotherapy alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Immuncell-LC (activated T lymphocytes) plus temozolomide
What this could lead to
If successful, this combination could improve progression-free survival and overall survival for people with newly diagnosed glioblastoma.
What could go wrong
This is a completed Phase 3 trial, but results are not yet widely confirmed. Glioblastoma is very aggressive, and even positive findings may offer only modest benefit. Risks include side effects from chemotherapy and the cell therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

180 people

The number who actually took part.

Started

Dec 2008

Finished

Oct 2012

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients who, prior to the study, received explanation of the purpose and content of study and of characteristics of the test drug from the test administrator and have consented to the study by providing signature of self, guardian, or legal representative. 2. Patients who are between 18 and 70 years of age 3. Patients whose cause of cancer has been found to be glioblastoma via pathological testing 4. patients who have received surgery for glioblastoma (Complete or partial extirpation or biopsy) 2 weeks prior to the study 5. Patients whose survival is expected to be longer than 3 months 6. Patients whose KPS is greater than 60 7. Patients who satisfy the following conditions of the blood test, kidney function test, and liver function test * Hemoglobin is bigger than 10 gm% * Platelet Count is bigger than 100,000/µL * Absolute granulocyte count is bigger than 1,500/µL * BUN or Creatinine 1.5 x upper normal limit * Bilirubin level is smaller than 2.0 mg/dL * SGOT, SGPT, alkaline phosphatase is smaller than 1.5 x upper normal limit Exclusion Criteria: 1. Patients who have been determined to have serious Cardio - Pulmonary function disability by the clinical study staff 2. Patients who are immune deficient or have a history of auto immune diseases (Ex. Rheumatoid Arthritis, Systemic Lupus Erythematosus, Vasculitis, Multiple sclerosis, Adolescent Insulin-Dependent Diabetes Mellitus, etc.) 3. Patients who have a history of malignant tumors in the recent 5 years prior to the study with the exception of skin cancer, local prostate cancer, and cervical cancer. 4. Patients with history of severe allergies 5. Patients with serious mental illness 6. Patients who are pregnant or nursing 7. Patients who have participated in other clinical tests in the recent 4 weeks prior to the study

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Gyunghee University Medical Center

    Seoul, South Korea

  • Hanyang University Guri Hospital

    Guri-si, Gyeonggi-do, South Korea

  • Konkuk University

    Seoul, South Korea

  • Korea University Anam Hospital

    Seoul, South Korea

  • Samsung Seoul Medical Center

    Seoul, South Korea

  • Seoul Asan Medical Center

    Seoul, South Korea

  • Yeonsei University Medical Center

    Seoul, South Korea

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