New imaging tracer aims to spot COPD damage early
NCT ID NCT02978144
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a radioactive tracer called Annexin to see if it can detect early lung damage in people with COPD and in smokers. Researchers compared scans from healthy non-smokers, healthy smokers, and people with moderate to severe COPD. The goal was to find a better way to diagnose lung damage early, but the study was stopped before completion.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
-
34 people
The number who actually took part.
- Started
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Jun 2017
- Finished
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Oct 2019
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with moderate COPD: Global Initiative for Chronic Obstructive Lung Disease (GOLD) Stage II, forced expiratory volume 1 (FEV1)/forced vital capacity (FVC) \< 0.7 and FEV1 50-79% predicted * Patients with severe COPD: GOLD Stage III-IV, FEV1/FVC \< 0.7 and FEV1 \< 50% predicted * Healthy controls who are currently smoking (\> 10 pack years) with normal spirometry (FEV1 \> 80% and FEV1/FVC \> 70%) * Healthy controls who never smoked (less than 100 lifetime cigarettes) with normal spirometry (FEV1 \> 80% and FEV1/FVC \> 70%) Exclusion Criteria: * Age \< 18 years
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Other studies related to the condition(s) this trial covers.
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