New cell therapy shows promise in battle against advanced skin cancer

NCT ID NCT06743126

Recruiting now Disease control Sponsor: Immatics US, Inc. Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated Apr 28, 2026 · Updated 22 times

Summary

This phase 3 trial tests a new cell therapy called IMA203 against standard treatments for people with advanced melanoma (a serious skin cancer) that has spread or can't be removed. About 360 adults who have already tried a PD-1 inhibitor will be randomly assigned to receive IMA203 or the doctor's choice of standard therapy. The main goal is to see if IMA203 delays cancer growth better than current options.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Atlantic Health System/Morristown Medical Center
RECRUITING

Morristown, New Jersey, 07960, United States

Contact
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
BC Cancer - Vancouver
ACTIVE_NOT_RECRUITING

Vancouver, British Columbia, V5Z 4E6, Canada
Baylor University
RECRUITING

Dallas, Texas, 75246, United States

Contact
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States

Contact Email: •••••@•••••
Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital
NOT_YET_RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Charite Universitaetsmedizin Berlin KöR
RECRUITING

Berlin, 12203, Germany
City of Hope National Medical Center
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
Cleveland Clinic, Taussig Cancer Institute
RECRUITING

Cleveland, Ohio, 44195, United States

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Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States

Contact Email: •••••@•••••
Goethe University Frankfurt
RECRUITING

Frankfurt am Main, 60590, Germany
Greater Glasgow and Clyde NHS, Beatson West of Scotland Cancer Center
NOT_YET_RECRUITING

Glasgow, G12 0YN, United Kingdom
Guy's and St Thomas' NHS Foundation Trust, Guy's Hospital
RECRUITING

London, SE1 9RT, United Kingdom
Honor Health Research Institute
RECRUITING

Scottsdale, Arizona, 85258, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

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Laura and Isaac Perlmutter Cancer Center at NYU Langone Health
RECRUITING

New York, New York, 10016, United States

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Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States

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Mayo Clinic
RECRUITING

Phoenix, Arizona, 85054, United States

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Mayo Clinic
ACTIVE_NOT_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Florida
ACTIVE_NOT_RECRUITING

Jacksonville, Florida, 32224, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States

Contact Email: •••••@•••••
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

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Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States

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Oxford University Hospitals NHS Foundation Trust, Churchill Hospital
NOT_YET_RECRUITING

Oxford, OX3 7LE, United Kingdom
Providence Cancer Institute Franz Clinic
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States

Contact Phone: •••-•••-••••
Stanford Cancer Center
RECRUITING

Stanford, California, 94305, United States

Contact Email: •••••@•••••
Technische Universitaet Dresden
RECRUITING

Dresden, 01307, Germany
The Christie NHS Foundation Trust
NOT_YET_RECRUITING

Manchester, M20 4GJ, United Kingdom
The Royal Marsden NHS Foundation Trust
NOT_YET_RECRUITING

London, SW3 6JJ, United Kingdom
The University of Texas MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
Thomas Jeffersion University, Sidney Kimmel Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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UC San Diego Moores Cancer Center
RECRUITING

La Jolla, California, 92093, United States

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UCLA Hematology/Oncology
RECRUITING

Los Angeles, California, 90024, United States

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UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94143, United States

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UNC Hospitals, The University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States

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UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States

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Contact
Universitaet Leipzig
RECRUITING

Leipzig, 04103, Germany
Universitaetsklinikum Bonn AöR
NOT_YET_RECRUITING

Bonn, 53127, Germany
Universitaetsklinikum Erlangen AöR
RECRUITING

Erlangen, 91054, Germany
Universitaetsklinikum Essen AöR
RECRUITING

Essen, 45147, Germany
Universitaetsklinikum Heidelberg AöR
RECRUITING

Heidelberg, 69120, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
RECRUITING

Mainz, 55131, Germany
Universitatsklinikum Koeln
RECRUITING

Cologne, Northrhine-W Estphalia, 50937, Germany
University Health Network, Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact Email: •••••@•••••
University Medical Center Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Colorado, Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States

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University of MD Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States

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University of Miami - Sylvester Comprehensive Cancer Cente
RECRUITING

Miami, Florida, 33136, United States

Contact Email: •••••@•••••
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States

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University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States

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University of Pennsylvania, Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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University of Rochester
RECRUITING

Rochester, New York, 14642, United States

Contact Email: •••••@•••••
University of Southampton NHS Foundation Trust, Southampton General Hospital
NOT_YET_RECRUITING

Southampton, SO16 6YD, United Kingdom
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23219, United States

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Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06510, United States

Contact

Conditions

Explore the condition pages connected to this study.

MELANOMA, CUTANEOUS MALIGNANT