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Light therapy restores immune balance in rare skin cancer

NCT ID NCT07235813

Knowledge-focused Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 16 people with mycosis fungoides, a rare skin lymphoma, and 16 healthy volunteers. Researchers measured a protein called IL-35, which can suppress the immune system, in blood and skin samples before and after phototherapy (light treatment). They found that IL-35 levels were much higher in patients than in healthy people, but dropped back to normal after phototherapy. The results suggest that phototherapy may help restore immune balance, and IL-35 could be used to track how well treatment is working.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Jan 2025

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Subjects with mycosis fungoides; newly diagnosed or recurrent after cessation of treatment * Both genders * Age group ≥ 18 years old Exclusion Criteria: * Patients with any contraindication to phototherapy (e.g., any other skin cancers or photosensitivity); or to psoralen (e.g., liver disease). * Subjects with history of solid or hematological malignancy as leukemia. * Patients with autoimmune disease as SLE. * Patients who received treatment for the past one month. * Pregnant and lactating females

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Conditions

The condition(s) this trial relates to.

mycosis fungoides

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mycosis fungoides

Contacts and locations

Locations

  • Kasr El Aini Hospital

    Cairo, English (English), 11511, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.