MYCOSIS FUNGOIDES

This early-phase trial tests a specially modified virus (VSV-hIFNβ-NIS) combined with two immunotherapy drugs (ipilimumab and cemiplimab) in adults with relapsed or refractory T-cell lymphoma. The virus is designed to kill cancer cells without harming healthy ones, while the immu…

This early-phase study tests a combination of two drugs, mogamulizumab and brentuximab vedotin, in people with a rare type of skin lymphoma (CTCL or MF) that has been treated before. The main goal is to find a safe dose and see how well the combination is tolerated. About 10 adul…

This study tests whether combining a very low dose of radiation to the whole skin (ULD-TSEBT) with a targeted drug called brentuximab vedotin can better control mycosis fungoides, a type of skin lymphoma. About 30 adults with stage I-IV disease that has come back or not responded…

This early-phase trial tests a new drug called ST-001 (a form of fenretinide) in people with T-cell non-Hodgkin lymphoma whose cancer has returned or not responded to prior treatments. The main goal is to find the safest dose and understand side effects. About 46 participants wil…

This study tests whether a blood-filtering treatment called photopheresis can improve early-stage cutaneous T-cell lymphoma (a type of skin cancer). About 74 adults with stage IA to IIA disease will receive the therapy, which is currently used only for advanced stages. The goal i…

This study tests whether ultra low dose radiation can control skin lesions in people with mycosis fungoides, a type of lymphoma. About 50 participants will receive targeted radiation to their skin spots. The goal is to shrink or control the lesions while reducing side effects com…

This study tests whether combining a topical immune-stimulating cream (imiquimod) with local radiation therapy is safe and effective for treating mycosis fungoides, a rare type of skin lymphoma. About 25 adults with early-stage disease who have not responded to standard treatment…

This study watches how safe and effective the drug mogamulizumab is for adults with mycosis fungoides or Sezary syndrome, two rare types of skin lymphoma. About 15 people will be followed during their normal treatment to track side effects and how well the drug controls the disea…

This early-phase trial tests whether a patient's own immune cells, modified in a lab to recognize and attack a protein called CCR4 on cancer cells, can safely treat certain T-cell lymphomas that have not responded to standard therapy. About 60 adults with relapsed or refractory p…

This study tests a drug called golidocitnib in people with certain slow-growing but incurable blood cancers (T/NK-cell lymphomas) that have not responded to standard treatment. About 48 adults will receive the drug to see if it shrinks tumors and how safe it is. The goal is to co…

This study is testing a lower dose of the drug brentuximab vedotin in people with mycosis fungoides, Sezary syndrome, or lymphomatoid papulosis—types of lymphoma that affect the skin. The goal is to see if the lower dose works as well as the standard dose but with fewer side effe…

This study tests a gel called HyBryte that, when activated by light, targets cancer cells in the skin. It is for people with early-stage cutaneous T-cell lymphoma (a rare type of skin lymphoma). About 80 participants will apply the gel to their skin lesions and then receive a spe…

This study follows 100 people who were diagnosed with juvenile-onset mycosis fungoides or lymphomatoid papulosis before age 20. Researchers will check their health status and ask them or their parents about long-term outcomes. The goal is to understand the safety and long-term ef…

This study collects blood, urine, and skin samples from 200 adults with cutaneous T-cell lymphoma, eczema, or atopic dermatitis. The samples are stored for current and future research to better understand these conditions. Participants must be 18 or older and have a confirmed dia…

This study is creating a large database of information from 1,000 people with T-cell lymphoma. Researchers will collect medical records and tumor samples to learn more about the disease and how to improve care. No new treatments are being tested; the goal is to gather data for fu…

This study is collecting standardized medical data from 2,000 people with advanced mycosis fungoides or Sézary syndrome, rare types of skin lymphoma. The goal is to create a new prognostic index that helps doctors identify which patients are at higher or lower risk, so they can t…