HIV breakthrough? drug may let patients ditch daily meds

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: * Age ≥ 18 and ≤ 70 years at the time of screening * Documented HIV-1 infection * On continuous ART for at least 6 months without any interruptions of greater than 14 consecutive days within the preceding 6 months * Plasma HIV RNA levels less than 200 copies/mL at each determination in the previous 6 months * Screening CD4+ T-cell count ≥ 350 cells/mm3 * Willingness to interrupt ART as part of the study transient treatment interruption Exclusion Criteria: * On an ART regimen that includes a non-nucleoside reverse transcriptase inhibitor, unable to switch to a different regimen * Receipt of any long-acting ART medication (e.g., injectable cabotegravir/rilpivirine, lenacapavir) in the two years preceding screening. * Known resistance to two or more classes of ART drugs and/or the inability to construct another fully suppressive regimen * Evidence of HIV "elite" control immediately prior to ART initiation * Screening platelets \< 125,000/mm3 * Screening hemoglobin \< 12.5 g/dL for men and \<11.5 for women * History of an AIDS-defining illness according to CDC criteria * History of HIV-associated malignancy * Non-HIV-associated malignancy requiring systemic chemotherapy or surgery in the 36 months preceding screening, or for whom such therapies are expected in the subsequent 12 months. * Active Hepatitis B (Hep B) infection (defined as Hep B surface antigen (sAg) positive or HBV DNA positive) * Active Hepatitis C (Hep C) infection (defined as Hep C Ab positive or indeterminate with detectable Hep C RNA) * Chronic liver disease * Chronic kidney disease * Active and poorly controlled atherosclerotic cardiovascular disease * QTc interval \>450msec (male) or \>470msec (female) * Pregnant, breastfeeding, or unwilling to use contraception to prevent pregnancy during participation in the study and until 6 months resumption of ART * Unable or unwilling to use barrier protection or pre-exposure prophylaxis (PrEP) in the partner, with sexual partners not known to have HIV