Scientists dig into mysterious immune cell deficiency
NCT ID NCT02113930
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at 47 people with a rare condition called idiopathic CD4 lymphocytopenia, where the body has too few CD4 immune cells. Researchers collected blood samples and genetic data to understand what causes the condition and how it affects patients. The goal was to improve diagnosis and identify who might benefit from future treatments like IL-2 therapy.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could help doctors better identify and understand idiopathic CD4 lymphocytopenia, potentially guiding future treatments.
- What could go wrong
- This is an observational study with only 47 participants, so findings may not apply to all patients. It does not test a new treatment directly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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47 people
The number who actually took part.
- Started
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Sep 2013
- Finished
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Sep 2017
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
200 patients will be included : 100 for which the diagnosis of ICL will be defined on a basis in international classification criteria.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Idiopathic CD4 lymphocytopenia defined as absolute CD4+ T-lymphocyte count \< 300/mm3 or \< 20% of total T cells on more than one cell count; no evidence of infection with HIV-1/2 or human T-cell lymphotropic 1/2 (HTLV-1/2); and lack of a defined immune-deficiency disease or therapy for lymphocytopenia. * Male and female patients can be included * Children and adults can be included * Hospitalized or outpatient Exclusion Criteria: * CD4+ lymphocytopenia due to another condition (HIV infection, sarcoidosis, malignant lymphoma). * Ongoing treatment possibly responsible for CD4 lymphocytopenia. * CD4+ lymphocytopenia related to primary immune deficiency * Absence of consent, of inability to obtain informed consent from the patients or the right holders. * Absence of affiliation to a social security regimen of the patient or the right holder.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cochin Hospital
Paris, 75014, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.