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Glowing dye could make spine surgery safer

NCT ID NCT05808140

Symptom relief Sponsor: Zhongnan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a green dye called indocyanine green (ICG) can help surgeons see and protect nerves during spine surgery for a slipped disc. Forty patients were split into groups: some got the dye and a special camera, others had standard surgery. The goal was to see if the dye makes finding nerves faster and safer, potentially reducing nerve damage that can cause numbness or weakness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Indocyanine Green (ICG)
What this could lead to
If it works, this could make spine surgery safer by helping surgeons avoid damaging nerves, reducing the risk of numbness or weakness after surgery.
What could go wrong
This is an early-phase trial with only 40 people, so results may not apply to everyone. The dye might not work well in all patients, and there is a small risk of allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

40 people

The number who actually took part.

Started

Apr 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with lumbar disc herniation based on symptoms and Imaging examination * Patients undergo endoscopy spinal surgery for nerve root decompression * Patients have no clear contraindications to surgery, and has the ability to understand and act and has informed consent, and can participate in all study follow-up voluntarily and signe a written informed consent form. Exclusion Criteria: * The patients have thyroid related diseases, including autonomous nodules * Patients are allergic to iodine or shellfish * Patients have ankylosing spondylitis, lumbar instability or bony spinal stenosis * Patients have diabetes, vascular related diseases, or abnormal liver and kidney function * Difficulty in tolerating anaesthesia * Pregnant or lactating women * Patients are unable to communicate or do not follow directions * The investigators consider the patient unsuitable to participate in this study

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Conditions

The condition(s) this trial relates to.

Intervertebral Disc Displacement lumbar disk herniation, susceptibility to

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Disc herniation

Contacts and locations

Locations

  • Department of Spine Surgery and Musculoskeletal Tumor, Zhongnan Hospital of Wuhan University

    Wuhan, Hubei, 430062, China

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Other studies related to the condition(s) this trial covers.