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Ibuprofen before a hot run may stress kidneys, small study finds

NCT ID NCT06247462

Knowledge-focused Sponsor: University of New Mexico Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether taking ibuprofen before running in the heat increases signs of kidney injury. Twelve healthy adults took either ibuprofen or a placebo before running for an hour in a hot room. Researchers measured kidney injury markers in urine and blood before, right after, and one hour after exercise. The goal was to see if ibuprofen makes the kidneys more vulnerable to heat and exercise stress.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Ibuprofen
What this could lead to
If it works, this could help clarify whether taking ibuprofen before exercise in the heat is safe for the kidneys.
What could go wrong
This is a very small, early-phase study with only 12 participants. Results may not apply to everyone, and the study only looked at short-term markers, not actual kidney damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

12 people

The number who actually took part.

Started

Jun 2023

Finished

Sep 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Physically active (engage in at least 150 minutes of moderate to vigorous intensity exercise per week) * between the ages of 18 and 45 * Able to run continuously for at least 60 minutes * Able to speak and read English. Exclusion Criteria: * Non-English speakers, prisoners, pregnant women, or persons requiring a LAR * Previous history of heat stroke or heat illness * Currently experiencing a sunburn or other burn injury * Have repeated exposure to heat, such as hot baths, sauna, or travel to a hot environment * Has resided in a hot climate within 2 months prior to the trial * Answered "yes" to at least one question on the physical activity readiness questionnaire * Shows signs or symptoms of or are known to have cardiovascular, renal, metabolic, or pulmonary disease as determined by a health questionnaire * Are a current smoker * History of regular gastrointestinal distress * Known history of stomach ulcers or taking blood thinning medication * Known allergy to ibuprofen * Have a resting blood pressure greater than 140 systolic or 90 diastolic * Do not engage in at least 150 minutes of moderate to vigorous intensity exercise per week.

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury

Contacts and locations

Locations

  • Exercise Physiology Lab

    Albuquerque, New Mexico, 87131, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.