Ibuprofen before a hot run may stress kidneys, small study finds
NCT ID NCT06247462
First seen Jan 29, 2026
Summary
This study looked at whether taking ibuprofen before running in the heat increases signs of kidney injury. Twelve healthy adults took either ibuprofen or a placebo before running for an hour in a hot room. Researchers measured kidney injury markers in urine and blood before, right after, and one hour after exercise. The goal was to see if ibuprofen makes the kidneys more vulnerable to heat and exercise stress.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
-
Exercise Physiology Lab
Albuquerque, New Mexico, 87131, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ibuprofen
What this could lead to
If it works, this could help clarify whether taking ibuprofen before exercise in the heat is safe for the kidneys.
What could go wrong
This is a very small, early-phase study with only 12 participants. Results may not apply to everyone, and the study only looked at short-term markers, not actual kidney damage.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.