Scientists probe gut leaks in IBS patients
NCT ID NCT00742118
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at colon tissue samples from 200 people with irritable bowel syndrome (IBS) to understand why their gut barrier may be leaky. Researchers tested whether substances released by mast cells (a type of immune cell) can damage the gut lining and nerves. The goal is to find new targets for IBS treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could point toward new treatments for IBS by targeting gut barrier problems.
- What could go wrong
- This is an observational study, not a treatment trial. Results may not lead directly to therapies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 200 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Feb 2008
- Finished
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Aug 2016
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients needing coloscopy Exclusion Criteria: * Disrupted coagulation results * Cancer even healed * Known food allergy. * Alcohol consumption \>30g/day
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Department of gastroenterology, Hopital Archet 2
Nice, 06002, France
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Other studies related to the condition(s) this trial covers.
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