New radiation regimen cuts treatment time for early glottic cancer
NCT ID NCT07197060
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a shorter, higher-dose radiation schedule (3.5 Gy per fraction for 17 sessions) for people with early-stage glottic cancer (T1-T2N0M0). The goal is to see if this approach controls the tumor as well as standard longer radiation, while being more convenient. About 70 adults who have not had prior larynx surgery or radiation will participate. The main outcome measured is local tumor control.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
patients with histologically confirmed squamous cell carcinoma of the glottisStage T1-T2N0M0 (AJCC 8th edition)based on clinical exam and imaging
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * • Histologically confirmed squamous cell carcinoma of the glottis * Stage T1-T2N0M0 (AJCC 8th edition) * (based on clinical exam and imaging) * Age ≥ 18 years * Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * No prior radiotherapy or surgery to the larynx (except biopsy) * Adequate organ function and a life expectancy of at least 6 months * Ability to comply with follow-up schedule and complete voice assessments * Signed informed consent Exclusion Criteria: * • Prior head and neck irradiation * Nodal involvement or distant metastasis * Poor vocal cord mobility or subglottic extension * Severe comorbidities or life expectancy \< 6 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
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How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
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