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Oxygen levels during surgery: does more help or hurt?

NCT ID NCT07525661

Knowledge-focused Sponsor: Istanbul University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how different oxygen levels during laparoscopic lower abdominal surgery affect stress markers in the lungs and blood. 76 adults were randomly assigned to receive either normal (35%) or high (80%) oxygen during surgery. Researchers measured changes in various biomarkers related to lung injury, inflammation, and blood vessel health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
oxygen (hyperoxia vs normoxia)
What this could lead to
If it works, this could help guide oxygen use during surgery to reduce stress on the lungs and blood vessels.
What could go wrong
This is a small, completed study that only measured biological markers, not patient outcomes. Results may not change practice without larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

76 people

The number who actually took part.

Started

Jul 2017

Finished

Feb 2019

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 to 70 years * Scheduled for elective laparoscopic lower abdominal surgery * Expected surgery duration of at least 90 minutes * ASA physical status I to III * Body mass index 18.5 to 35 kg/m2 * Planned management under standardized general anesthesia with volume-controlled ventilation Exclusion Criteria: * Known chronic pulmonary disease, including chronic obstructive pulmonary disease or asthma requiring regular medication * Baseline peripheral oxygen saturation below 92% on room air * Significant cardiovascular instability * Severe hepatic or renal dysfunction * Active infection or systemic inflammatory disease * Use of systemic corticosteroids or immunosuppressive therapy * Pregnancy * Inability to provide informed consent * Anticipated difficult airway * Expected need for postoperative mechanical ventilation

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Conditions

The condition(s) this trial relates to.

Hyperoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endothelial glycocalyx injury Hyperoxia Oxidative stress Perioperative care

Contacts and locations

Locations

  • Istanbul University, Istanbul Faculty of Medicine

    Istanbul, Turkey (Türkiye)

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