New painkiller strategy may help moms recover faster after C-Section
NCT ID NCT06823180
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed study tested whether giving a low or high dose of hydromorphone (a morphine-like drug) before the end of a C-section can reduce pain afterward. 105 women were split into three groups: low dose, high dose, or a placebo. Researchers measured pain scores, how soon women could move and breastfeed, and any side effects. The goal is to find the best dose for safer, faster recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hydromorphone hydrochloride
- What this could lead to
- If it works, this could provide a better way to manage pain after C-section, helping mothers recover faster and breastfeed more easily.
- What could go wrong
- This is a small, completed Phase 4 trial, so results may not apply to all women. The drug can cause side effects like nausea or drowsiness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
105 people
The number who actually took part.
- Started
-
Mar 2025
- Finished
-
Aug 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
22 to 45 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Parturients with indications for cesarean section; * American Association of Anesthesiologists (ASA) Grade I - II; * No history of sedative drugs or opioid abuse; * Volunteer to join the study Exclusion Criteria: * People with coagulation disorders; * preoperative use of analgesia, non-steroidal drugs; * Abnormal liver and kidney function; * Postoperative drainage is urgently needed.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Jiangxi Provincial People's Hospital
Nanchang, Jiangxi, 330038, China
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