Gel could soothe pain after gum grafts, small study finds
NCT ID NCT05821725
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a gel made from hyaluronic acid (a natural substance in the body) can help heal wounds on the roof of the mouth after gum graft surgery. Thirty adults aged 18 to 70 took part, and researchers measured wound size and pain levels over six weeks. The goal was to see if the gel improves healing and reduces discomfort compared to standard care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hyaluronic acid gel
- What this could lead to
- If it works, this gel could reduce pain and speed healing after gum graft surgery, making recovery more comfortable for patients.
- What could go wrong
- This is a small, completed trial with only 30 participants. Results may not apply to everyone, and the gel may not significantly improve healing over standard care.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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30 people
The number who actually took part.
- Started
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Jul 2023
- Finished
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Nov 2023
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Males and females, between 18-70 years of age * Informed Consent Form signed and availability for the duration of the study * Good general health (absence of any condition that, in the opinion of the Principal Investigator, might constitute a risk to the subject while participating in the study * Clinical indication for mucogingival surgery that requires a de-epithelialized gingival graft (DGG) from the palate * Willingness to provide information related to their medical history * Minimum of 10 uncrowned permanent natural teeth (excluding third molars) * Normal salivary flow Exclusion Criteria: * Oral pathology, chronic disease, or a history of allergy to testing products * Subject using anticonvulsants, antihistamines, antidepressants, sedatives, tranquilizers, anti-inflammatory medication or daily analgesics within one month prior to the start of the study or scheduled to start such intake during the course of the study * Subject participating in any other clinical study * Subject pregnant or breastfeeding * Subject allergic to oral care products, personal care consumer products, or their ingredients * Extended use of antibiotics or therapeutic mouthwash any time during the three months prior to entry into the study * A medical history reporting that the subject has a current systemic or autoimmune disease, such as diabetes, lupus, etc * Ongoing use of medications known to affect the gingival tissues (i.e. calcium channel blockers, phenytoin, cyclosporine)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Faveri Academy
Guarulhos, São Paulo, 04081-010, Brazil
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