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New shot combo aims to silence hepatitis b virus

NCT ID NCT07245953

First seen Dec 10, 2025 · Last updated May 20, 2026 · Updated 27 times

Summary

This study tests two experimental injections, HT-101 and HT-102, in 60 adults with chronic hepatitis B who are already on standard antiviral therapy. The goal is to see if the combination can lower hepatitis B surface antigen (HBsAg) to undetectable levels and keep the virus under control. Participants will be monitored for safety and long-term effects.

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Contacts and locations

Locations

  • Beijing Ditan Hospital Capital Medical University

    Beijing, Beijing Municipality, 100015, China

  • Guangzhou Eighth People's Hospital, Guangzhou Medical University

    Guangzhou, Guangdong, 510440, China

  • Henan Infectious Diseases Hospital , The Sixth People's Hospital of Zhengzhou

    Zhengzhou, Henan, 450000, China

  • Mengchao Hepatobiliary Hospital of Fujian Medical University

    Fuzhou, Fujian, 350028, China

  • Nanchang Ninth Hospital

    Nanchang, Jiangxi, 330022, China

  • Nanfang Hospital

    Guangzhou, Guangdong, 510515, China

  • Qingyuan People's Hospital

    Qingyuan, Guangdong, 511518, China

  • Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine

    Nanning, Guangxi, 530011, China

  • Shanghai Public Health Clinical Center

    Shanghai, Shanghai Municipality, 200083, China

  • Sichuan Provincial People's Hospital

    Chengdu, Sichuan, 610072, China

  • The Second Hospital of Nanjing

    Nanjing, Jiangsu, 210003, China

  • Zhenjiang Third People's Hospital (Zhenjiang Infectious Diseases Hospital)

    Zhenjiang, Jiangsu, 212021, China

Conditions

Explore the condition pages connected to this study.