Can a vaccine clear HPV after cervical lesion surgery?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Common eligibility criteria for the study (for both cohorts) : 1. Female patient over 45 years old 2. Patient treated by conization for high-grade cervical epithelial lesion 3. Positive HPV test at the 6-month post-operative control (a delay of 6 to 12 months will be accepted), leading to an indication for a control colposcopy (+/- biopsy) according to standard surveillance practices. 4. N.B. : Patients with abnormalities at the initial control colposcopy and/or positive biopsy remain eligible for the study, whether vaccinated or not. 2. Additional eligibility criteria for the clinical trial (Vaccinated patients cohort) 1. No contraindication to HPV vaccination with Gardasil 9 2. Patient consented to HPV vaccination with Gardasil 9 3. Affiliated with a social security system 4. Informed and signed written consent provided 5. N.B. : Patients infected with HIV are eligible for the vaccine trial provided they are on antiretroviral therapy. 3. Inclusion criteria for the data study (Non-vaccinated patients cohort) 1. Patient eligible for the study (a) and not eligible for the clinical trial (b) due to: * refusal of vaccination, or * A contraindication to vaccination 2. No objection to the use of their personal data for research purposes N.B. : A patient who initially refused vaccination may later request to be vaccinated as part of the trial after signing the consent form. The vaccine trial analysis will include all patients who started vaccination within 6 months after the initial HPV control test. Exclusion Criteria: 1. Common exclusion criteria for the study (for both cohorts) 1. History of primary HPV vaccination 2. History of HPV-induced invasive cancer (cervical, vaginal, vulvar, anal, oropharyngeal cancer) 2. Exclusion criteria for the clinical trial (Vaccinated patients cohort) 1. Patient refusing HPV vaccination 2. Patient with a contraindication to HPV vaccination with Gardasil 9 3. Patient deprived of liberty or under guardianship 3. Exclusion criteria for the data study (Non-vaccinated patients cohort) a) Opposition to the use of their personal data for research purposes