Could a vaccine replace radiation for throat cancer?

NCT ID NCT06223568

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Sep 30, 2025 · Last updated May 21, 2026 · Updated 30 times

Summary

This study tests whether adding an experimental vaccine (PRGN-2009) to standard chemotherapy can help people with HPV-positive throat cancer avoid radiation and its side effects. About 70 adults with newly diagnosed, surgically removable throat cancer will receive chemo alone or chemo plus the vaccine. After treatment, they will have surgery to remove the tumor and be followed for two years to see if the combination leads to better outcomes.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-••••

Conditions

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CANCER VACCINE CANCER VACCINE DRUG THERAPY HUMAN PAPILLOMAVIRUS VIRUSES OROPHARYNX SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK