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Ultra-Processed foods hijack your metabolism and brain, study finds

NCT ID NCT06017986

Knowledge-focused Sponsor: Virginia Polytechnic Institute and State University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how eating ultra-processed foods (like packaged snacks) affects your metabolism and brain compared to minimally processed foods (like whole fruits and vegetables). Fifty-seven healthy adults ate both types of meals in a special room that measured their energy use, blood sugar, and insulin. They also did a task in an MRI scanner to see how much they valued different foods. The goal was to understand why people overeat ultra-processed foods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

57 people

The number who actually took part.

Started

Jul 2023

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Self report BMI between 18.5-24.9 kg/m2 * Not pregnant or planning to become pregnant during study participation Residing in the Roanoke area and/or willing/able to attend sessions at the Fralin Biomedical Research Institute * Able to speak and write in English * Participants must be able to see a computer display clearly with or without vision correction (eyeglasses, contacts). Exclusion Criteria: * Claustrophobia (this would make lying in an MRI scanner or indirect calorimetry canopy very uncomfortable). 2\. History of head injury resulting in loss of consciousness for more than 10 minutes 3. Current or past diagnosis of diabetes or metabolic disorder (thyroid disease, etc.) 4. Contraindications to MRI: Individuals with pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants. 5\. History of alcohol or drug dependence 6. Active neurologic disorder 8. Diagnosed eating disorder 9. Food allergies or restrictive diet

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Conditions

The condition(s) this trial relates to.

metabolic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolic diseases

Contacts and locations

Locations

  • Fralin Biomedical Research Institute at VTC

    Roanoke, Virginia, 24016, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.