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Study reveals how everyday drugs influence your mood and decisions

NCT ID NCT03652740

Knowledge-focused Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how common medications like methylphenidate and nicotine affect mood and drug preference in 25 healthy adults. Participants rated their liking and perceived value of the drugs. The goal was to understand the psychological effects of these medications, not to treat any condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Methylphenidate and nicotine
What this could lead to
If successful, this could help researchers understand how everyday medications affect mood and decision-making.
What could go wrong
This is a small, early-phase study in healthy volunteers, so results may not apply to people with medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

25 people

The number who actually took part.

Started

Oct 2018

Finished

Feb 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 * Fluent in written and spoken English and is capable of understanding and complying with the protocol * Medically healthy * Non-smoker * Appropriate dietary/over-the-counter/prescription/illicit drug use history * Body Mass Index between 18.5 and 35 * Appropriate use of birth control in females e.g., barrier methods, hormonal contraceptives, Intra Uterine Devices (IUDs) Exclusion Criteria: * Known hypersensitivity to administered drugs * Current neurological, hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary or metabolic disease for which administration of the study drugs would be contraindicated * Current psychiatric or substance use condition that would interfere with study participation * Diastolic blood pressure \>90 mmHg or a systolic pressure of \>140 mmHg * Use of medications that would interfere with study participation * Past prescriptions that may affect study participation * Unwilling or unable to comply with the protocol * Any other serious disease or condition that might affect life expectancy or make it difficult to successfully manage the subjects according to the protocol * Females: Pregnancy, breastfeeding, or plans to become pregnant

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy

Contacts and locations

Locations

  • Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Center

    Baltimore, Maryland, 21224, United States

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