Hormone Therapy's hidden effects: new study eyes metabolism and heart risks
NCT ID NCT04838249
First seen Jan 04, 2026 · Last updated Jun 23, 2026 · Updated 25 times
Summary
This study observes 80 transgender individuals starting cross-sex hormone therapy (testosterone or estrogen) to see how it changes eating behavior, metabolism, weight, and heart health. Participants are followed over time with no extra treatments or procedures. The goal is to understand how sex hormones influence the body, which could help prevent obesity, diabetes, and heart disease in this group.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADIPOSITY are added.
Genom att skicka in godkänner du våra Användarvillkor
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
Genom att skicka in godkänner du våra Användarvillkor
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Helmholtz Institute for Metabolic, Obesity and Vascular Research
RECRUITINGLeipzig, Saxony, 04103, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
testosterone and estradiol/antiandrogens
What this could lead to
If successful, this study could reveal how sex hormones influence weight, metabolism, and heart disease risk, potentially improving long-term care for transgender individuals.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly test a new therapy. Results may not apply to all populations, and the small size (80 participants) limits generalizability.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.