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Thyroid treatment may not fully restore metabolic health, study finds

NCT ID NCT07616570

Knowledge-focused Sponsor: Başakşehir Çam & Sakura City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 88 women newly diagnosed with primary hypothyroidism (underactive thyroid) to see if taking levothyroxine to normalize thyroid hormones also improves metabolic health. Researchers measured special proteins called adipokines, which are linked to fat tissue and metabolism, before and after 8 weeks of treatment. The goal was to understand if hormonal recovery means full metabolic recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

88 people

The number who actually took part.

Started

Dec 2025

Finished

Apr 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of premenopausal female patients aged 18 years or older who were newly diagnosed with primary hypothyroidism at the Internal Medicine outpatient clinic and had not previously received levothyroxine or any other thyroid hormone replacement therapy. Participants were evaluated before treatment initiation and after 8 weeks of standard-of-care levothyroxine replacement therapy. Only patients who completed both baseline and follow-up assessments were included in the final analysis.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged 18 years or older * Premenopausal status * Newly diagnosed primary hypothyroidism, defined by elevated serum TSH level above the reference range with low free T4 level * No previous use of levothyroxine or other thyroid hormone replacement therapy * Ability and willingness to provide written informed consent * Completion of both baseline and 8-week follow-up assessments Exclusion Criteria: * Known hypothalamic or pituitary disease * Previous thyroid hormone replacement therapy * Pregnancy or lactation * Menopause * History of thyroid surgery or radioactive iodine therapy * Active malignancy * Acute or chronic inflammatory disease * Severe hepatic or renal disease * Diabetes mellitus * Use of medications known to significantly affect thyroid function, glucose metabolism, lipid metabolism, or adipokine levels * Inability or unwillingness to provide informed consent or comply with follow-up requirements

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome Arachnodactyly Dyslipidemias hypothyroidism Insulin Resistance metabolic syndrome X

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypothyroidism Metabolic syndrome Primary hypothyroidism

Contacts and locations

Locations

  • University of Health Sciences Basaksehir Cam and Sakura City Hospital

    Istanbul, 34480, Turkey (Türkiye)

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