New pill to fight poisoning passes first safety check in humans
NCT ID NCT05628961
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early study tested single doses of HOPO 14-1 in 42 healthy adults to see if it is safe and how the body handles it. HOPO 14-1 is designed to bind and remove toxic metals like uranium or plutonium. The trial was completed, but results are not yet available.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- HOPO 14-1 (a drug designed to remove toxic metals from the body)
- What this could lead to
- If successful, this could lead to a treatment for heavy metal poisoning.
- What could go wrong
- This is a very early Phase 1 study in healthy people, not patients. It only tests safety and how the drug moves through the body, not whether it works for poisoning. Side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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42 people
The number who actually took part.
- Started
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Mar 2023
- Finished
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Aug 2025
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ability of participant to understand the requirements of the study, provide written informed consent, and agree to abide by the study requirements * Agree to use contraception from time of screening until 14 days after dosing (Day 14) if female is of childbearing potential or male is with female partner of childbearing potential. * In good general health based on medical history, physical examination (PE), and screening evaluations. * Negative urine screen for drugs of abuse (except if participant provides prescription justifying use prior to urine screen). * Body weight ≥ 50 kilogram (kg) and ≤ 110 kg. If body weight is over 110 kg, then body mass index (BMI) will be considered and must be ≤ 40 kg/m\^2. Exclusion Criteria: * Inability or unwillingness of a participant to give written informed consent or comply with study protocol. * Any hematology, chemistry, coagulation, or urinalysis value on screening labs defined in the United States Food and Drug Administration (FDA) Guidance for Industry Toxicity Grading Scale as Grade 1 or higher. * Any clinically significant electrocardiogram (ECG) abnormality * Pregnant or breastfeeding * Active substance abuse or history of any medical or psychiatric condition that would jeopardize the participant's safety or the participant's ability to comply with the protocol. * Received an organ transplant (solid or bone marrow). * Received a blood transfusion within 3 months of dosing. * Difficulty swallowing tablets or capsules. * Febrile illness or significant infection within 7 days of dosing. * Symptoms of hypotension (lightheadedness, syncope, balance disturbances, or extreme fatigue) within 48 hours of dosing. * Hepatitis B virus surface antigen (HBsAg) positive or serologic (antibody positive) evidence of infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV). * Tested positive for SARS-CoV-2 (COVID-19) within 21 days of dosing. * Chelation therapy (e.g., ethylenediaminetetraacetic acid \[EDTA\], diethylenetriamine pentaacetate \[DTPA\]) in the past year. * Use of laxatives, antibiotics, and/or antacids within 7 days of dosing. * Use of investigational drugs within 60 days of dosing or 5 half-lives, whichever is longer. * Received a vaccination within 30 days of dosing. * Potential allergic reaction to product (oleic acid or HOPO 14-1 product). * Past or current medical problems or findings from physical examination (PE) or laboratory testing
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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SRI International Clinical Trials Unit
Plymouth, Michigan, 48170, United States