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New pill to fight poisoning passes first safety check in humans

NCT ID NCT05628961

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tested single doses of HOPO 14-1 in 42 healthy adults to see if it is safe and how the body handles it. HOPO 14-1 is designed to bind and remove toxic metals like uranium or plutonium. The trial was completed, but results are not yet available.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
HOPO 14-1 (a drug designed to remove toxic metals from the body)
What this could lead to
If successful, this could lead to a treatment for heavy metal poisoning.
What could go wrong
This is a very early Phase 1 study in healthy people, not patients. It only tests safety and how the drug moves through the body, not whether it works for poisoning. Side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

42 people

The number who actually took part.

Started

Mar 2023

Finished

Aug 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ability of participant to understand the requirements of the study, provide written informed consent, and agree to abide by the study requirements * Agree to use contraception from time of screening until 14 days after dosing (Day 14) if female is of childbearing potential or male is with female partner of childbearing potential. * In good general health based on medical history, physical examination (PE), and screening evaluations. * Negative urine screen for drugs of abuse (except if participant provides prescription justifying use prior to urine screen). * Body weight ≥ 50 kilogram (kg) and ≤ 110 kg. If body weight is over 110 kg, then body mass index (BMI) will be considered and must be ≤ 40 kg/m\^2. Exclusion Criteria: * Inability or unwillingness of a participant to give written informed consent or comply with study protocol. * Any hematology, chemistry, coagulation, or urinalysis value on screening labs defined in the United States Food and Drug Administration (FDA) Guidance for Industry Toxicity Grading Scale as Grade 1 or higher. * Any clinically significant electrocardiogram (ECG) abnormality * Pregnant or breastfeeding * Active substance abuse or history of any medical or psychiatric condition that would jeopardize the participant's safety or the participant's ability to comply with the protocol. * Received an organ transplant (solid or bone marrow). * Received a blood transfusion within 3 months of dosing. * Difficulty swallowing tablets or capsules. * Febrile illness or significant infection within 7 days of dosing. * Symptoms of hypotension (lightheadedness, syncope, balance disturbances, or extreme fatigue) within 48 hours of dosing. * Hepatitis B virus surface antigen (HBsAg) positive or serologic (antibody positive) evidence of infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV). * Tested positive for SARS-CoV-2 (COVID-19) within 21 days of dosing. * Chelation therapy (e.g., ethylenediaminetetraacetic acid \[EDTA\], diethylenetriamine pentaacetate \[DTPA\]) in the past year. * Use of laxatives, antibiotics, and/or antacids within 7 days of dosing. * Use of investigational drugs within 60 days of dosing or 5 half-lives, whichever is longer. * Received a vaccination within 30 days of dosing. * Potential allergic reaction to product (oleic acid or HOPO 14-1 product). * Past or current medical problems or findings from physical examination (PE) or laboratory testing

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • SRI International Clinical Trials Unit

    Plymouth, Michigan, 48170, United States