Brain zaps and workouts: new hope for MS fatigue?
NCT ID NCT07567989
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a home exercise program combined with a gentle brain stimulation technique (tDCS) can reduce fatigue in people with multiple sclerosis. Sixty participants will either get real tDCS or a sham version alongside their exercises. The goal is to see if the combo works better than exercise alone for improving energy and daily function.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Oct 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Signed written informed consent * Confirmed diagnosis of multiple sclerosis * Presence of fatigue associated with multiple sclerosis, defined as a fatigue Visual Analogue Scale (VAS) score equal to or greater than 4 * Functional capacity sufficient to perform the Six-Minute Walk Test (6MWT), assessed by a Functional Ambulation Category (FAC) score of 3 or higher Exclusion Criteria: * Presence of any neurological, rheumatological, or other medical condition prior to the diagnosis of multiple sclerosis that could interfere with the study outcomes * Presence of contraindications for transcranial direct current stimulation (tDCS), such as having a pacemaker, a history of epillepsy, pregnancy, implanted intracranial electrodes, defibrillator, or similar electronic devices. * Cognitive impairment that limits the participant's ability to collaborate with study procedures. * Any changes in physical therapy or pharmacological treatments for multiple sclerosis and/or fatigue that are not specified by the study protocol. * Occurrence of a multiple sclerosis relapse or disease progression with functional repercussions during the study period.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
3 sites. The list below names each one and where it is.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Complexo Hospitalario Universitario de A Coruña
A Coruña, A Coruña, 15009, Spain
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Complexo Hospitalario Universitario de Santiago de Compostela
Santiago de Compostela, A Coruña, 15706, Spain
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Complexo Hospitalario Universitario de Vigo
Vigo, Pontevedra, 36214, Spain
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Other studies related to the condition(s) this trial covers.
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- Can PET scans reveal hidden brain inflammation in MS?
- Can a pill rebuild the Brain's insulation? MS trial puts remyelination to the test
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