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At-Home brain zaps show promise for MS fatigue

NCT ID NCT05890885

Symptom relief Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a safe, non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) could reduce fatigue in people with multiple sclerosis (MS). Ten adults with MS-related fatigue used a home-based tDCS device. The goal was to see if it could improve tiredness, mood, and thinking. The study was small and completed, but results are not yet widely reported.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

10 people

The number who actually took part.

Started

Sep 2022

Finished

Apr 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Definite MS diagnosis according to the 2017 McDonald criteria * Fatigue since more than 6 months as assessed by fatigue severity scale (FSS\>5) * Age between 18 and 75 years. * Stable pharmacological and physical treatment since at least one month * Affiliation to the social security regimen * Signature of the informed consent * Ability of the patient to understand the instructions for use of the pacemaker to ensure safe use Exclusion Criteria: * Relapses within the last two months * Active medical device implanted * Intracranial metal implants * Craniotomy, cranial trepanation, aneurysm * Uncontrolled epilepsy * Non-weaned alcoholism, sleep debt * Expanded disability status scale ≥ 6.5 * Severe depression based on Beck Depression inventory (BDI\>19) * Daytime sleepiness based on Epworth Sleepiness Scale (ESS\> 11) * Other neurologic and psychiatric diseases * Known pregnancy by the investigator or breastfeeding * Physical or mental incapacity to give informed consent * Participation in another study (exclusion period following a previous study should be ≥ 6 months) * Patients on AME * Patients under legal protection * Prisoners

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Conditions

The condition(s) this trial relates to.

Fatigue multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Fatigue in multiple sclerosis

Contacts and locations

Locations

  • Assistance Publique Hôpitaux de Paris-Hôpital Henri Mondor

    Créteil, 94000, France

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Other studies related to the condition(s) this trial covers.