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HMB and exercise: a closer look at muscle building

NCT ID NCT05444959

Knowledge-focused Sponsor: Poznan University of Physical Education Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how a supplement called HMB, combined with exercise, affects muscle proteins and fitness in two groups: trained athletes and people who are not very active or are malnourished. Over 21 days, participants took HMB or a placebo and underwent exercise tests. The goal was to measure changes in muscle-building signals and hormone levels, not to treat a disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
beta-hydroxy-beta-methylbutyric acid (HMB) free acid supplement
What this could lead to
If successful, this could help explain how HMB and exercise together influence muscle building and fitness, potentially guiding future sports nutrition or recovery strategies.
What could go wrong
This is a small, early-stage study focused on biological markers, not clinical outcomes. Results may not translate to real-world benefits or apply to broader populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

130 people

The number who actually took part.

Started

Sep 2021

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * written informed consent from all participants before the study * a current medical clearance to practice sports, * Group S: regular physical activity (\> 250 minutes per week), training practice (\> 10 years), * Group W: a subjects characterized by lack of regular physical activity that never were trained in competitive sports and certain features of malnutrition/low physical fitness, Exclusion Criteria: * current injury, * any health-related contraindication, * declared general feeling of being unwell, * unwilling to follow the study protocol, * serious disease or metabolic problems, * intake of ergogenic supplements 3 months before the beginning of the study, * history of anabolic androgenic steroids or drugs use that may interfere with muscle mass control (eg, corticosteroids), or affect physical performance, * smoking and tobacco use, * presence of infectious disease in the previous 4 weeks of the study

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aerobic capacity Fat free mass Protein kinases SPORT Sports dietetics Sports nutrition Supplementation

Contacts and locations

Locations

  • Department of Physiology and Biochemisty at the Faculty of Physical Education and Sport (Charles University, Prague, Czech Republic)

    Prague, Prague 6, 162 52, Czechia

  • Department of Sports Dietetics, Poznan University of Physical Education

    Poznan, Wielkopolska, 61-871, Poland

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