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Brotherly advice: sibling talks may boost HIV prevention

NCT ID NCT05805306

Prevention Sponsor: Charles Drew University of Medicine and Science Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether training siblings to talk about HIV PrEP helps Latino men who have sex with men start taking it. 288 participants were split into two groups: one where siblings learned to discuss PrEP, and another where siblings discussed vaccines instead. The goal was to see if the PrEP conversations led more men to begin using PrEP.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
sibling-led PrEP promotion conversations
What this could lead to
If successful, this approach could offer a new way to increase HIV PrEP use among young Latino men, potentially reducing HIV infections in this community.
What could go wrong
This is a completed behavioral study, not a drug trial. The outcome depends on whether sibling conversations actually change behavior, which may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

288 people

The number who actually took part.

Started

Apr 2023

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 39 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Latino Men Who Have Sex with Men 1. self-identify as Latino 2. identify as male 3. be \<40 years old 4. report HIV-negative status 5. be willing to talk about MSM healthcare issues with a sibling 6. either (a) have never used PrEP or (b) stopped using PrEP at least 90 days ago 7. missing most recent COVID vaccine 8. missing Hepatitis (A or B) vaccines 9. missing Mpox vaccine 10. meet CDC's PrEP eligibility criteria (be HIV-negative; any male sex partner in the past six months; not in a monogamous partnership with a recently tested, HIV-negative man; and at least one of the following: any anal sex without condoms in past 6 months, any sexually-transmitted infection (STI) diagnosed or reported in past 6 months, or is in an ongoing sexual relationship with an HIV-positive male partner). Exclusion Criteria: Latino Men Who Have Sex with Men 1. are unable to provide consent or 2. they do not meet any of the criteria above Inclusion Criteria: Siblings 1. at least 18 years old 2. report a close relationship his/her LMSM brother \<40 years old 3. be willing to talk about MSM healthcare issues with his/her LMSM brother Exclusion Criteria: Siblings 1. are unable to provide consent or 2. they do not meet any of the criteria above

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Conditions

The condition(s) this trial relates to.

Homosexuality HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV infections

Contacts and locations

Locations

  • Charles R. Drew University of Medicine and Science

    Los Angeles, California, 90059, United States

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Other studies related to the condition(s) this trial covers.