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New vaginal insert shows promise in early HIV/HSV prevention trial

NCT ID NCT06087913

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 31 times

Summary

This early-stage study tested a vaginal insert containing two drugs (tenofovir alafenamide and elvitegravir) to prevent HIV and herpes (HSV) infection. Sixty-eight healthy women used the insert daily for 3 days, then every other day for 14 days. The main goal was to check safety and measure drug levels in the body and vaginal fluids.

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Contacts and locations

Locations

  • CAPRISA eThekwini Clinical Research Site

    Durban, South Africa

  • Eastern Virginia Medical School Clinical Research Clinic (EVMS CRC)

    Norfolk, Virginia, 23507, United States

  • Kenya Medical Research Institute (KEMRI)

    Thika, Kenya

Conditions

Explore the condition pages connected to this study.