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New MRI technique could prevent unnecessary brain surgery for benign tumor

NCT ID NCT04285125

Knowledge-focused Sponsor: Fondation Ophtalmologique Adolphe de Rothschild Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether ultra-high-resolution MRI can more clearly identify a rare, benign brain tumor called MVNT. Currently, standard MRI may leave the diagnosis uncertain, leading some patients to undergo surgery for a harmless growth. Researchers will scan 33 adults with suspected MVNT and compare standard and advanced MRI images over two years to see if the new technique improves diagnosis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to more accurate MRI-based diagnosis of MVNT, sparing patients from invasive brain surgery for a benign lesion.
What could go wrong
This is a small, early-stage observational study (33 people) focused on imaging, not treatment. The ultra-high-resolution MRI may not significantly improve diagnosis over standard scans.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 33 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2020

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with suspicion of MVNT during a first exploratory MRI.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patient over 18 years of age * Prospective inclusion of all patients with suspected MVNT on a first exploratory MRI: at least the 2 major criteria associated with at least 1 minor criterion will be required to fit into the definition of suspected MVNT: * Major criteria : * Multinomodular clustered appearance * Franc hypersignal FLAIR/T2 * Minor criteria : * No mass effect * Hyposignal T1 * Having received informed information about the study and having given express consent to participate in the study Exclusion Criteria: * Contraindication to MRI * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman Secondary exclusion criteria: \- No characterization MRI done

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Conditions

The condition(s) this trial relates to.

multinodular and vacuolating neuronal tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Benign neuronal desease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU Rennes

    RECRUITING

    Rennes, Rennes, 35033, France

  • CHU de Rouen

    ACTIVE_NOT_RECRUITING

    Rouen, Rouen, 76000, France

  • Centre Hospitalier Lyon Sud

    ACTIVE_NOT_RECRUITING

    Pierre-Bénite, 69495, France

  • Fondation A De Rothschild

    RECRUITING

    Paris, 75019, France

  • Groupe Hospitalier Pellegrin

    ACTIVE_NOT_RECRUITING

    Bordeaux, Bordeaux, 33076, France

  • Hôpital Laennec

    RECRUITING

    Saint-Herblain, 44800, France

  • Hôpital Pierre Paul Riquet, CHU Purpan

    ACTIVE_NOT_RECRUITING

    Toulouse, Toulouse, 31059, France

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