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Exercise as medicine: HIIT may slow glaucoma damage

NCT ID NCT06058598

Disease control Sponsor: Henner Hanssen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether high-intensity interval training (HIIT) can improve eye health and slow disease progression in people with glaucoma. 168 adults aged 40-75 with open-angle glaucoma will be randomly assigned to either a supervised HIIT program or standard care with lifestyle advice. The main goal is to see if exercise improves blood vessel function in the retina, which could help control the disease and enhance quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 168 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Voluntary written informed consent of the participant has been obtained prior to any screening procedures * Patients with primary open angle glaucoma (POAG), high tension glaucoma (HTG) and normal tension glaucoma (NTG), aged 40 - 75 years * In regular follow-up in either of the two study centres Exclusion Criteria: * Patients having had glaucoma surgery within 6 months before start of the project * Patients with changes in topical medication or laser trabeculoplasty within 3 months before start of the project * Patients with very severe glaucoma (visual field mean deviation lower than -12Db) * Significant opacification of ocular media * Patients with life-threatening arrhythmia, signs of ischemia during CPET which preclude participation in an exercise trial * Patients with insulin treated diabetes, chronic obstructive pulmonary disease or cancer. * Patients doing ≥1 structured exercise training session per week or \>150min of exercise/week assessed via the following two questions: a. On average, how many days per week do you engage in moderate to vigorous physical activity (like brisk walking)? b. On average, how many minutes per day do you engage in physical activity at this level? Calculate the total weekly minutes of exercise by multiplying a times b. * Mental or physical limitation precluding participation in a high intensity exercise program

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Conditions

The condition(s) this trial relates to.

low tension glaucoma open-angle glaucoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Exercise training Glaucoma, open-angle Microvascular health

Contacts and locations

Locations

  • University of Basel, Department of Sport, Exercise & Health

    Basel, 4052, Switzerland

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Other studies related to the condition(s) this trial covers.