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Can High-Flow oxygen prevent dangerously low oxygen during awake intubation?

NCT ID NCT07384494

Disease control Sponsor: Wenxian Li Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This study compares high-flow nasal cannula (HFNC) oxygen therapy to standard low-flow oxygen in patients who need a breathing tube while awake due to a difficult airway. The goal is to see if HFNC better prevents dangerously low oxygen levels during the procedure. About 336 adults from six hospitals in China will take part.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
High-flow nasal cannula (HFNC) oxygen therapy
What this could lead to
If it works, this could provide a safer way to keep oxygen levels up during awake intubation, reducing complications.
What could go wrong
This is a relatively small, early-stage trial, and results may not apply to all patients. The intervention is a device, not a drug, so benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 336 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presence of an anticipated difficult airway; * Planned awake tracheal intubation; * Age ≥ 18 years; * Willingness to participate in the study and provision of written informed consent. Exclusion Criteria: * Contraindications to HFNC use, such as severe nasal obstruction or deformity, recent (within 3 months) nasal or skull base surgery, skull base fracture, or active epistaxis; * Hemodynamic instability, defined as a mean arterial pressure (MAP) \< 65 mmHg or the need for vasoactive medications to maintain blood pressure; * Pregnancy; * Current participation in another interventional clinical trial.

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Conditions

The condition(s) this trial relates to.

Hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Awake tracheal intubation Difficult airway

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    6 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baoding No.1 Central Hospital

    NOT_YET_RECRUITING

    Baoding, Hebei, China

  • Eye & ENT Hospital of Fudan University

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Pizhou Hospital of Traditional Chinese Medicine

    RECRUITING

    Pizhou, Jiangsu, China

  • South China Hospital of Shenzhen University

    RECRUITING

    Shenzhen, Guangzhou, China

  • The First People's Hospital of Neijiang

    NOT_YET_RECRUITING

    Neijiang, Sichuan, China

  • Wuwei People's Hospital

    RECRUITING

    Wuwei, Gansu, China

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