Can High-Flow oxygen prevent dangerously low oxygen during awake intubation?

NCT ID NCT07384494

Recruiting now Disease control Sponsor: Wenxian Li Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This study compares high-flow nasal cannula (HFNC) oxygen therapy to standard low-flow oxygen in patients who need a breathing tube while awake due to a difficult airway. The goal is to see if HFNC better prevents dangerously low oxygen levels during the procedure. About 336 adults from six hospitals in China will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: High-flow nasal cannula (HFNC) oxygen therapy
What this could lead to: If it works, this could provide a safer way to keep oxygen levels up during awake intubation, reducing complications.
What could go wrong: This is a relatively small, early-stage trial, and results may not apply to all patients. The intervention is a device, not a drug, so benefits may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AWAKE TRACHEAL INTUBATION DIFFICULT AIRWAY

Contacts and locations

Locations

Baoding No.1 Central Hospital
NOT_YET_RECRUITING

Baoding, Hebei, China
Eye & ENT Hospital of Fudan University
RECRUITING

Shanghai, Shanghai Municipality, China
Pizhou Hospital of Traditional Chinese Medicine
RECRUITING

Pizhou, Jiangsu, China
South China Hospital of Shenzhen University
RECRUITING

Shenzhen, Guangzhou, China
The First People's Hospital of Neijiang
NOT_YET_RECRUITING

Neijiang, Sichuan, China
Wuwei People's Hospital
RECRUITING

Wuwei, Gansu, China

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