Xenon gas vs standard anesthetic: which keeps blood pressure steadier during carotid surgery?
NCT ID NCT00937807
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed Phase 4 trial tested whether xenon gas (LENOXe) can keep blood pressure as stable as sevoflurane during carotid artery surgery in 84 elderly patients. The study measured blood pressure changes every minute during surgery. Researchers also looked at safety, recovery quality, and pain levels. The goal was to see if xenon is a good alternative for this specific procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- xenon gas
- What this could lead to
- If xenon proves non-inferior to sevoflurane, it could offer an alternative anesthetic with similar blood pressure stability for elderly patients undergoing carotid surgery.
- What could go wrong
- This is a small, completed Phase 4 trial with only 84 participants. Results may not apply to broader populations or other surgeries. Xenon is expensive and not widely available.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
84 people
The number who actually took part.
- Start date
-
Jul 2009
- Finished
-
Apr 2010
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
55 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients \> 55 years, status ASA II * Carotid endarterectomy elected surgery * Signed informed consent Exclusion Criteria: Related to the patients: * Histories of hypersensibility in both products used in the study * uncontrolled arterial High Blood Pressure in the preoperative anaesthesia screening * Severe cardiac failure (FEVG \< 30 %) * Major lung or airways disease and\\or required per-operating FiO2\> 35 % * Elevated intracranial pressure * Pregnancy, breast feeding * Major protected, under supervision, under guardianship * Every patient entering within the framework of the contraindications indicated to §4.3 of the summary of the characteristics of tested products (LENOXe ™ (xenon 100 % v/v), sevoflurane) Related to the surgery: * Controlateral carotid stenosis superior to 70 % and\\or preoperative indication in the implementation per-operating of a carotid shunt * Surgery realized within the framework of an emergency * Combined Surgery
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hospital Pitié-Salpêtrière
Paris, 75013, France
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