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Heavy periods and loose joints: a hidden connection?

NCT ID NCT05685199

Knowledge-focused Sponsor: St. Jude Children's Research Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at women and girls aged 12 to 40 with heavy menstrual bleeding to see if they also have joint hypermobility (loose joints). Researchers wanted to find out if these two issues together might point to an underlying connective tissue disorder. The study was stopped early, but it aimed to improve understanding of these conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

15 people

The number who actually took part.

Started

May 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants who meet the Eligibility criteria and consent

Ages

12 to 40 years

Sex

Female participants only

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female * Age 12-40 years * Presence of HMB * Evidence of severe iron-deficiency anemia (hemoglobin level of \< 8 g/dL) Exclusion Criteria: * Inability or unwillingness of research participant or legal guardian/representative to give written informed consent. * Current use of anticoagulant and antiplatelet medications * Currently pregnant * Medical conditions that could cause HMB but are not necessarily a bleeding disorder, including, but not limited to: * Uncontrolled hypertension * Documented uterine structural abnormality * Insulin-dependent diabetes mellitus * Chronic kidney disease * Chronic liver disease * Thyroid disease * Documented peripheral arterial disease, venous or arterial vascular events in the past * A structural pathology that would explain the HMB * Presence of a bleeding disorder indicated by prothrombin time, activated partial thromboplastin time, fibrinogen, and von Willebrand factor activity, antigen and factor VIII * Persistent thrombocytopenia as defined by a platelet count of \<150,000/uL * If the participant answers "yes" to any of the following questions, they are ineligible: * Could the patient have a known connective tissue disorder? * Family history of sudden death * Family history/personal history of uterine rupture or bowel perforation * Family history/personal history of arterial rupture * Family history/personal history of aneurysm * Family history/personal history of an established EDS diagnosis based on genetic evaluation

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Conditions

The condition(s) this trial relates to.

Ehlers-Danlos syndrome, hypermobility type hypermobility syndrome Joint Instability Menorrhagia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heavy menstrual bleeding Hypermobile Ehlers-Danlos syndrome Hypermobility syndrome (disorder)

Contacts and locations

Locations

  • St. Jude Children's Research Hospital

    Memphis, Tennessee, 38105, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.