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New study tests if low oxygen makes heat stress worse for workers

NCT ID NCT07664462

Knowledge-focused Sponsor: University of Ottawa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This study looks at whether low oxygen levels (like at high altitudes) increase the risk of heat stress during moderate work in hot environments. Twenty healthy young and older men will walk on a treadmill in a hot room, once with normal oxygen and once with low oxygen. Researchers will measure body temperature, heart strain, and other signs to see if current safety guidelines need updating for combined heat and low-oxygen conditions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could lead to better safety guidelines for workers exposed to both heat and low oxygen, such as at high altitudes.
What could go wrong
This is a small, early-stage study with only 20 healthy male participants, so results may not apply to women or people with health conditions. It is designed to gather knowledge, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Are male. * Do not smoke or have been smoke free for at least 5 years. * English or French speaking. * Ability to provide informed consent. * Are physically active (engage in exercise at least 2 times per week for ≥30 minutes) Exclusion Criteria: * Are regularly exposed to hot environments (e.g., occupational heat exposure) * Are regularly exposed to hypoxic environments (e.g., high altitudes) * Experience claustrophobia or discomfort in enclosed environments * Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness). * Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy). * Uncontrolled hypertension - BP \>150 mmHg systolic or \>95 mmHg diastolic in a sitting position. * Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.). * Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable. * Cardiac abnormalities identified during screening

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Conditions

The condition(s) this trial relates to.

altitude sickness Body Temperature Changes Heat Stress Disorders Hyperthermia Hypoxia Motor Activity occupation-related stress disorder Occupational Stress

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Body temperature changes Heat exposure Heat fatigue Heat stress Hypoxia, altitude Physiological stress Work related stress

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Ottawa

    RECRUITING

    Ottawa, Ontario, K1N 6N5, Canada

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