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Scientists probe kidney damage after heart surgery to find clues for prevention

NCT ID NCT06772025

Knowledge-focused Sponsor: Bayer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 27, 2026 · Updated 4 times

Summary

This study is observing 200 adults scheduled for heart surgery to understand why some develop acute kidney injury afterward. Researchers will collect blood and urine samples before and after surgery to measure biomarkers linked to kidney damage. No experimental treatments are given—participants receive standard care. The goal is to uncover mechanisms that could lead to future prevention strategies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify early warning signs and potential targets for future treatments to prevent kidney injury after heart surgery.
What could go wrong
This is an observational study with no treatment being tested, so it will not directly help participants. Results may not lead to new therapies for years, if at all.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant must be at least 18 years of age at the time of signing the informed consent form (ICF). * Participants who are scheduled for hospital admission for any of the following cardiovascular surgery interventions, alone or in combination, involving cardiopulmonary bypass (CPB): * Aortic, mitral, or tricuspid valve surgery (repair or replacement) * Aortic surgery * ≥3 coronary artery bypass grafts * Participant with: chronic kidney disease (CKD): 30 ≤ estimated glomerular filtration rate (eGFR) \< 90 mL/min/1.73 m\^2 Exclusion Criteria: * Emergency surgery situation * Anemia - hemoglobin \<10 g/dL * Clinical signs of systemic infection or other infection requiring anti-infective treatment (viral, bacterial, fungal, parasitic; single-dose prophylaxis allowed) * Systemic immunosuppressive or anti-inflammatory treatment including corticosteroids \>10 mg prednisolone equivalent/day * Any anti-cancer treatment within 3 months (e.g. immunotherapy, chemotherapy, radiotherapy) * Major surgery within 2 months * AKI within the last month * Prior renal transplants or RRT * Planned use of contrast media within 5 days prior to surgery or during surgery * Patient included in an interventional clinical trial involving a pharmacological intervention * Any reason that would make participation unadvisable, at the discretion of the investigator. * Autoimmune disorders such as anti-glomerular basement membrane (anti-GBM) diseases, systemic lupus erythematosus, chronic rheumatic heart diseases, acute rheumatic heart pericarditis, endocarditis, myocarditis, rheumatic mitral valve diseases, rheumatic aortic valve diseases

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac surgery associated - acute kidney injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Harefield Hospital | Cardiology

    RECRUITING

    Harefield, Greater London, UB9 6JH, United Kingdom

  • Herz- und Diabeteszentrum Nordrhein-Westfalen

    RECRUITING

    Bad Oeynhausen, North Rhine-Westphalia, 32545, Germany

  • Royal Papworth Hospital | Cardiac Surgery

    RECRUITING

    Cambridge, Cambridgeshire, CB2 0AY, United Kingdom

  • St Thomas' Hospital | Critical Care

    RECRUITING

    London, Greater London, SE1 7EH, United Kingdom

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