Breathing exercises and brain games may slow Alzheimer's risk, study suggests

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * speak English fluently * between the age of 50-70 * healthy adult who weighs at least 110 pounds * non-pregnant and non-menstruating (for at least the past year) * normal or corrected-to-normal vision and hearing * have a home computer with a physical keyboard and have access to reliable internet * have an email account that you check regularly * have a phone that receives text messages * willing to provide a blood sample and a urine sample at three lab visits * willing to devote up to 60 minutes daily to the study for 12 weeks (in addition to lab visits) Exclusion Criteria: * have a disorder that would impede performing the breathing intervention (e.g., abnormal cardiac rhythm, heart disease including coronary artery disease, angina, and arrhythmia, cognitive impairment, dyspnea) * regularly practicing any relaxation, biofeedback, or breathing technique (e.g., meditation) for more than an hour a week * regularly played Lumosity games in the past 6 months * participated in heart rate biofeedback studies in the USC Emotion \& Cognition Lab * have any conditions listed below that are not safe for MRI * Claustrophobia * Have worked as a machinist, metal worker, or in any profession or hobby grinding metal? * Have had an injury to the eye involving a metallic object (e.g., metallic slivers, shavings, or foreign body) * Cardiac pacemaker * Implanted cardiac defibrillator * Aneurysm clip or brain clip * Carotid artery vascular clamp * Neurostimulator * Insulin or infusion pump * Spinal fusion stimulator * Cochlear, otologic, ear tubes or ear implant * Prosthesis (eye/orbital, penile, etc.) * Implant held in place by a magnet * Heart valve prosthesis * Artificial limb or joint * Other implants in body or head * Electrodes (on body, head or brain) * Intravascular stents, filters * Shunt (spinal or intraventricular) * Vascular access port or catheters * IUD * Transdermal delivery system or other types of foil patches (e.g., Nitro, Nicotine, Birth control, etc.) that cannot be removed for MRI * Shrapnel, buckshot, or bullets * Tattooed eyeliner or eyebrows * Body piercing(s) that cannot be removed for MRI * Metal fragments (eye, head, ear, skin) * Internal pacing wires * Aortic clips * Metal or wire mesh implants * Wire sutures or surgical staples * Harrington rods (spine) * Bone/joint pin, screw, nail, wire, plate * Wig or toupee that cannot be removed for MRI * Hair implants that involve staples or metal * Hearing aid(s) that cannot be removed for MRI * Dentures or retainers that cannot be removed for MRI