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Heart scans reveal hidden dangers of untreated preeclampsia

NCT ID NCT06099275

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study aims to measure how well the heart pumps blood in people with untreated preeclampsia compared to healthy pregnant women. Researchers will use a non-invasive ultrasound (echocardiography) to check heart function at rest, after blood pressure medication, and during delivery and recovery. The study plans to enroll 80 participants but is currently suspended.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand how preeclampsia affects the heart, potentially leading to improved monitoring or treatment approaches.
What could go wrong
This is an observational study, not a treatment trial, so it won't directly change patient care. The study is currently suspended, and results may not apply to all patients with preeclampsia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

80 pregnant people will be recruited; 40 with preeclampsia, and 40 healthy normotensive pregnant people.

Ages

18 to 55 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Preeclampsia Participant. 1. Preclampsia definition: People with preeclampsia will be recruited at the time of diagnosis or suspected diagnosis of preeclampsia, according to accepted definitions of preeclampsia. Preeclampsia with severe features will be defined using the American College of Obstetrics and Gynecology definition. 2. Nulliparous, singleton pregnancy, 3. ≥20 weeks gestation 4. without any preexisting cardiovascular, hepatic, or respiratory problems, 5. No preexisting uterine abnormality including benign tumors, or placental adhesive disorder, 6. Not in labor, 7. Not with prior to treatment for preeclampsia, 8. Body mass index ≤ 40 kg/m2, age 18 to 50 years. Healthy Participant: Healthy pregnant people will be defined as 1. American Society of Anesthesiologists (ASA) Classification II with no significant medical or surgical illness, 2. Nulliparous (first pregnancy beyond 20 week's gestation) 3. Non-smokers, singleton pregnancy 4. Not having ruptured membranes 5. No uterine abnormalities 6. No placentation abnormalities. 7. Not receiving any vasoactive medication including salbutamol 8. Not on thyroid replacement hormones Exclusion Criteria: Preeclampsia Participant: 1. Multiparous, multiple pregnancy, 2. Previous cardiovascular, hepatic or respiratory problems 3. Gestational diabetes, 4. Hemodynamic or neurologically unstable patient 5. Unable to tolerate a 30-minute ultrasound examination (TTE) 6. Age less than 18 or greater than 50 years 7. BMI \> 40 kg/m2, 8. Gestation \< 20 weeks. Healthy Participant: 1. Current administration of vasoactive drugs including salbutamol 2. Current administration of thyroxine 3. Pre-existing or gestational diabetes 4. Tobacco use 5. Pre-existing or gestational hypertension or preeclampsia 6. Known uterine abnormality, in labor or ruptured membranes 7. Unable to tolerate a 30-minute ultrasound examination (TTE) 8. Age less than 18 or greater than 50 years 9. BMI \> 40 kg/m2, 10. Gestation \< 20 weeks.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.