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New pill could help heart failure patients walk farther and feel better

NCT ID NCT06991257

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental pill (PF-07328948) for adults with heart failure. About 620 participants will receive either the drug or a placebo to see if it improves walking distance and heart-related symptoms over 36 weeks. The goal is to manage the condition and reduce the risk of worsening heart failure or death.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 620 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 79 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

This study is seeking participants who are: Key Inclusion Criteria include: * aged 18 years to \< 80 years * clinically confirmed to have a diagnosis of heart failure for at least 3 months * New York Heart Association Class II-IV symptoms * left ventricular ejection fraction greater than 40% * Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85 * Six-minute walking distance greater than 75 meters Key Exclusion Criteria include: * Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body. * Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor. * History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes * Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    140 sites in 13 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • "Multiprofile Hospital for Active Treatment Puls" AD

    RECRUITING

    Blagoevgrad, 2700, Bulgaria

  • ACV Clinic

    RECRUITING

    Greater Sudbury, Ontario, P3E 5M4, Canada

  • AGEL Stredomoravska nemocnicni, a.s., Nemocnice AGEL Prerov

    RECRUITING

    Přerov, 751 52, Czechia

  • Amavita Research Services

    RECRUITING

    North Miami Beach, Florida, 33169, United States

  • Ascension Saint Agnes Heart Care

    RECRUITING

    Baltimore, Maryland, 21229, United States

  • BKS Research Kft

    RECRUITING

    Hatvan, Heves County, 3000, Hungary

  • CEPIC - Centro Paulista de Investigação Clínica

    RECRUITING

    São Paulo, 04266-010, Brazil

  • CHU de Quebec - Université Laval - Hotel Dieu de Quebec

    RECRUITING

    Québec, Quebec, G1R 2J6, Canada

  • CHUS - Hospital Clinico Universitario

    NOT_YET_RECRUITING

    Santiago de Compostela, A Coruña [LA Coruña], 15706, Spain

  • CIUSSS- saguenay-Lac-Saint-Jean

    RECRUITING

    Chicoutimi, Quebec, G7H 5H6, Canada

  • CMed Rehabilitacios es Diagnosztikai Kozpont

    RECRUITING

    Székesfehérvár, Fejér, 8000, Hungary

  • CardioQuest Research Centre

    RECRUITING

    Sarnia, Ontario, N7T 4P5, Canada

  • Cardresearch - Cardiologia Assistencial e Pesquisa

    RECRUITING

    Belo Horizonte, Minas Gerais, 30150-274, Brazil

  • Centre Hospitalier intercommunal de Toulon La Seyne sur Mer

    RECRUITING

    Toulon, Provence-Alpes-Côte d'Azur Region, 83100, France

  • Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur.

    RECRUITING

    Terrebonne, Quebec, J6V 2H2, Canada

  • Centro Avançado De Pesquisa, Estudos E Diagnóstico (CAPED) - Centro Médico RibeirãoShopping

    RECRUITING

    Ribeirão Preto, São Paulo, 14026-900, Brazil

  • Chesapeake Cardiac Care

    NOT_YET_RECRUITING

    Bowie, Maryland, 20715, United States

  • Chicago Medical Research

    RECRUITING

    Hazel Crest, Illinois, 60429, United States

  • China-Japan Union Hospital

    NOT_YET_RECRUITING

    Changchun, Jilin, 130033, China

  • Chu Grenoble Alpes

    RECRUITING

    Grenoble, 38700, France

  • Clinical Site Partners, LLC dba Flourish Research

    RECRUITING

    Winter Park, Florida, 32789, United States

  • Clinique de Médecins Spécialistes

    RECRUITING

    Shebrooke, Quebec, J1E 0N8, Canada

  • Community Care Building

    RECRUITING

    Winchester, Ontario, K0C 2K0, Canada

  • Comprehensive Cardiovascular Care

    RECRUITING

    Santa Maria, California, 93454, United States

  • CoraCentro Pesquisa Clinica

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90840-440, Brazil

  • Corcare

    RECRUITING

    Toronto, Ontario, M1B 5N1, Canada

  • Da Vinci Magánklinika

    RECRUITING

    Pécs, Baranya, 7635, Hungary

  • Diagnostic Consultative Center "Ascendent"

    RECRUITING

    Sofia, Sofia (stolitsa), 1202, Bulgaria

  • Diagnostic Consultative Center - 1 Lom EOOD

    RECRUITING

    Lom, Montana, 3600, Bulgaria

  • Diagnostic Consultative Center Aleksandrovska

    RECRUITING

    Sofia, Sofia (stolitsa), 1431, Bulgaria

  • Diex Recherche Sherbrooke Est

    RECRUITING

    Sherbrooke, Quebec, J1E 0N8, Canada

  • Diex Recherche Trois-Rivieres

    RECRUITING

    Trois-Rivières, Quebec, G9A 4P3, Canada

  • EDUMED s.r.o.

    RECRUITING

    Jaroměř, 551 01, Czechia

  • EFERTUS healthcare s.r.o.

    RECRUITING

    Brno-Židenice, 615 00, Czechia

  • Eszak-Pesti Centrumkorhaz-Honvedkorhaz

    RECRUITING

    Budapest, 1134, Hungary

  • Ezüstfény Klinika Kft

    RECRUITING

    Budapest, 1106, Hungary

  • FOMAT Medical Research

    RECRUITING

    Santa Maria, California, 93454, United States

  • FWD Clinical Research

    ACTIVE_NOT_RECRUITING

    Boca Raton, Florida, 33486, United States

  • Fakultni nemocnice Hradec Kralove

    RECRUITING

    Hradec Králové, 500 05, Czechia

  • Flourish Research - Bowie

    NOT_YET_RECRUITING

    Bowie, Maryland, 20715, United States

  • Flourish Research Acquisition, LLC dba Flourish Research - North Miami

    RECRUITING

    Miami, Florida, 33138, United States

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto

    RECRUITING

    São José do Rio Preto, São Paulo, 15090000, Brazil

  • Guangdong Provincial People's Hospital

    RECRUITING

    Guangzhou, Guangdong, 510080, China

  • Hainan General Hospital

    RECRUITING

    Haikou, Hainan, 570311, China

  • Headlands Horizons, LLC dba Headlands Research-Brownsville

    RECRUITING

    Brownsville, Texas, 78526, United States

  • Health Sciences North Research Institute

    RECRUITING

    Greater Sudbury, Ontario, P3E 5J1, Canada

  • Hospital Clinico de Valencia

    RECRUITING

    Valencia, Valenciana, Comunitat, 46010, Spain

  • Hospital General Universitario de Valencia

    NOT_YET_RECRUITING

    Valencia, 46014, Spain

  • Hospital Universitari Vall d'Hebron

    RECRUITING

    Barcelona, Barcelona [barcelona], 08035, Spain

  • Hospital Universitari de Bellvitge

    NOT_YET_RECRUITING

    L'Hospitalet de Llobregat, Catalunya [cataluña], 08907, Spain

  • Hospital Universitari i Politecnic La Fe

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, Madrid, Comunidad de, 28046, Spain

  • Hospital Universitario Puerta de Hierro

    RECRUITING

    Majadahonda, Madrid, 28220, Spain

  • Hospital Universitario Ramón y Cajal

    RECRUITING

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Hospital de la Santa Creu i Sant Pau

    RECRUITING

    Barcelona, Catalunya [cataluña], 08041, Spain

  • Hôpital Arnaud de Villeneuve - CHU Montpellier

    RECRUITING

    Montpellier, Hérault, 34090, France

  • Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes

    RECRUITING

    Saint-Herblain, Loire-atlantique, 44800, France

  • Incor - Instituto do Coracao

    RECRUITING

    São Paulo, 05403-000, Brazil

  • Infinite Clinical Research

    RECRUITING

    Miami, Florida, 33133, United States

  • Instituto de Pesquisa clinica de Campinas

    RECRUITING

    Campinas, São Paulo, 13060-080, Brazil

  • Jacksonville Center for Clinical Research

    RECRUITING

    Jacksonville, Florida, 32216, United States

  • Jahn Ferenc Dél-pesti Hospital

    RECRUITING

    Budapest, 1204, Hungary

  • Jinan Central Hospital

    RECRUITING

    Jinan, Shandong, 250013, China

  • Kardio Brynow

    RECRUITING

    Katowice, Silesian Voivodeship, 40-555, Poland

  • Kardiologicka ambulance Brno s.r.o.

    RECRUITING

    Brno-Královo Pole, 612 00, Czechia

  • Kasugai Municipal Hospital

    RECRUITING

    Kasugai, Aichi-ken, 486-8510, Japan

  • Kishiwada Tokushukai Hospital

    RECRUITING

    Kishiwada, Osaka, 596-0042, Japan

  • Koga General Hospital

    RECRUITING

    Koga, Ibaraki, 306-0041, Japan

  • L2IP - Instituto de Pesquisas Clínicas

    RECRUITING

    Brasília, Federal District, 70.200-730, Brazil

  • L2IP - Instituto de Pesquisas Clínicas

    RECRUITING

    Brasília, Federal District, 70200730, Brazil

  • Lanzhou university second hospital

    RECRUITING

    Lanzhou, Gansu, 730030, China

  • MHAT - Heart and Brain

    ACTIVE_NOT_RECRUITING

    Pleven, 5804, Bulgaria

  • MHAT Hadzhi Dimitar

    RECRUITING

    Sliven, 8800, Bulgaria

  • Medical Center Hera - Kyustendil EOOD

    RECRUITING

    Kyustendil, 2500, Bulgaria

  • Medical Center Hera EOOD

    RECRUITING

    Sofia, 1510, Bulgaria

  • Multiprofile Hospital for Active Treatment "Knyaginya Klementina" - Sofia EAD

    RECRUITING

    Sofia, Sofia (stolitsa), 1233, Bulgaria

  • Multiprofile Hospital for Active Treatment Dr. Tota Venkova AD

    RECRUITING

    Gabrovo, 5300, Bulgaria

  • NMH Clinical Research Unit

    RECRUITING

    Chicago, Illinois, 60611, United States

  • NZOZ Centrum Medyczne KERmed

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-231, Poland

  • NZOZ Sopockie Centrum Badan Kardiologicznych Pro Cordis Pawel Miekus

    RECRUITING

    Sopot, Pomeranian Voivodeship, 81-717, Poland

  • Nagasaki Harbor Medical Center

    RECRUITING

    Nagasaki, 850-8555, Japan

  • Nagoya Tokushukai General Hospital

    RECRUITING

    Kasugai, Aichi-ken, 487-0016, Japan

  • National Heart Institute

    RECRUITING

    Beverly Hills, California, 90211, United States

  • National Hospital Organization Iwakuni Clinical Center

    RECRUITING

    Iwakuni, Yamaguchi, 740-8510, Japan

  • National Hospital Organization Mie Chuo Medical Center

    RECRUITING

    Tsu, Mie-ken, 514-1101, Japan

  • National Hospital Organization Saitama Hospital

    RECRUITING

    Wako, Saitama, 351-0102, Japan

  • National Hospital Organization Sendai Medical Center

    RECRUITING

    Sendai, Miyagi, 983-8520, Japan

  • National Hospital Organization Tokyo Medical Center

    RECRUITING

    Meguro-Ku, Tokyo, 152-8902, Japan

  • National Hospital Organization Yokohama Medical Center

    RECRUITING

    Yokohama, Kanagawa, 245-8575, Japan

  • New Medical Center Kft.

    RECRUITING

    Sopron, H-9400, Hungary

  • NewHeart Watanabe Institute

    RECRUITING

    Suginami, Tokyo, 168-0065, Japan

  • NexGen Research

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

  • NexGen Research

    RECRUITING

    Lima, Ohio, 45801, United States

  • Ninewells Hospital and Medical School

    RECRUITING

    Dundee, Dundee CITY, DD1 9SY, United Kingdom

  • Norfolk and Norwich University Hospitals NHS Foundation Trust

    RECRUITING

    Norwich, Norfolk, NR4 7UY, United Kingdom

  • North Dallas Research Associates

    RECRUITING

    McKinney, Texas, 75069, United States

  • Northwest Houston Heart Center

    RECRUITING

    Tomball, Texas, 77375, United States

  • Northwestern Memorial HealthCare - Arkes Pavilion

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Northwestern Memorial HealthCare - Feinberg Pavilion

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Northwestern Memorial HealthCare - Galter Pavilion

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Northwestern Memorial Hospital Investigational Drug Service (IDS)

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Northwestern University

    RECRUITING

    Evanston, Illinois, 60208, United States

  • Núcleo de Pesquisa Clínica do Rio Grande do Sul

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90430-001, Brazil

  • Orange County Research Center

    RECRUITING

    Lake Forest, California, 92630, United States

  • Parc de Salut Mar - Hospital del Mar

    RECRUITING

    Barcelona, Barcelona [barcelona], 08003, Spain

  • Peking University First Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100034, China

  • QEII Health Sciences Centre - Victoria General Site

    RECRUITING

    Halifax, Nova Scotia, B3H 3A7, Canada

  • Reid Physician Associates

    RECRUITING

    Richmond, Indiana, 47374, United States

  • Research and Cardiovascular Corp.

    RECRUITING

    Ponce, 00717, Puerto Rico

  • Richmond Clinical Trials

    RECRUITING

    Richmond, British Columbia, V6V 2L1, Canada

  • SP ZOZ w Puławach

    RECRUITING

    Puławy, Lublin Voivodeship, 24-100, Poland

  • Sagamihara Kyodo Hospital

    RECRUITING

    Sagamihara, Kanagawa, 252-5188, Japan

  • Sdružené Zdravotnické Zařízení Krnov

    RECRUITING

    Krnov, Moravian-Silesian Region, 794 01, Czechia

  • Seikeikai New Tokyo Heart Clinic

    RECRUITING

    Matsudo, Chiba, 271-0077, Japan

  • Sekino Hospital

    RECRUITING

    Toshimaku, Tokyo, 171-0014, Japan

  • Semmelweis Egyetem

    RECRUITING

    Budapest, 1122, Hungary

  • Shaanxi provincial people's hospital

    RECRUITING

    Xi'an, Shaanxi, 710068, China

  • Shanghai Tongji Hospital

    RECRUITING

    Shanghai, Shanghai Municipality, 200065, China

  • Showa General Hospital

    RECRUITING

    Kodaira-shi, Tokyo, 187-8510, Japan

  • South Eastern Health and Social Care Trust

    RECRUITING

    Belfast, BT16 1RH, United Kingdom

  • St Richard's Hospital

    RECRUITING

    Chichester, WEST Sussex, PO19 6SE, United Kingdom

  • St. George's Hospital

    RECRUITING

    London, England, SW17 0QT, United Kingdom

  • Teine Keijinkai Hospital

    RECRUITING

    Sapporo, Hokkaido, 006-8555, Japan

  • The First Affiliated Hospital of University of South China

    RECRUITING

    Hengyang, China

  • The First Hospital of Hebei Medical University

    NOT_YET_RECRUITING

    Shijiazhuang, Hebei, 050031, China

  • The Second Xiangya Hospital of Central South University

    RECRUITING

    Changsha, Hunan, 410011, China

  • Tianjin People' s Hospital

    RECRUITING

    Tianjin, Tianjin Municipality, 300000, China

  • Toho University Sakura Medical Center

    RECRUITING

    Sakura, Chiba, 285-8741, Japan

  • Tokyo Metropolitan Toshima Hospital

    RECRUITING

    Itabashi-ku, Tokyo, 173-0015, Japan

  • UNESP - Faculdade de Medicina da Universidade Estadual Paulista

    RECRUITING

    Botucatu, SÃO PAUL, 18618-970, Brazil

  • University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD

    RECRUITING

    Plovdiv, 4002, Bulgaria

  • University Multiprofile Hospital for Active Treatment Sveta Ekaterina EAD

    RECRUITING

    Sofia, Sofia (stolitsa), 1431, Bulgaria

  • Uniwersytecki Szpital Kliniczny w Poznaniu

    RECRUITING

    Poznan, Greater Poland Voivodeship, 61-848, Poland

  • VASOMED Clinic s.r.o.

    RECRUITING

    Ostrava, 710 00, Czechia

  • Valley Regional Medical Center

    RECRUITING

    Brownsville, Texas, 78526, United States

  • Velocity Clinical Research, Lincoln, Pioneer Heart Institute

    RECRUITING

    Lincoln, Nebraska, 68510, United States

  • Winchester District Memorial Hospital

    RECRUITING

    Winchester, Ontario, K0C 2K0, Canada

  • Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu

    RECRUITING

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland

  • Wycombe General Hospital

    RECRUITING

    High Wycombe, HP11 2TT, United Kingdom

  • Yokohama Municipal Citizen's Hospital

    RECRUITING

    Yokohama, Kanagawa, 221-0855, Japan

  • Zhongshan Hospital,Fudan University

    NOT_YET_RECRUITING

    Shanghai, Shanghai Municipality, 200032, China

  • Аcibadem City Clinic University MHAT EOOD - Third Clinical Base

    RECRUITING

    Sofia, 1415, Bulgaria

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