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Could a simple handgrip prevent fainting? new study investigates

NCT ID NCT06939153

Knowledge-focused Sponsor: Tracy Baynard Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the heart and blood vessels communicate when blood pressure drops, like when standing up quickly. Researchers will test young and older men and women using a vacuum chamber around the legs to safely mimic low blood pressure. They will also see if squeezing a handgrip helps protect against blood pressure drops. The goal is to better understand why some people, especially older women, feel dizzy or faint, and whether a simple exercise could help.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could point toward simple handgrip exercises as a way to prevent dizziness and fainting when standing up, especially in older adults.
What could go wrong
This is a small, early-stage observational study with only 64 participants. It does not test a treatment, so any practical advice would require much larger follow-up trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 64 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * People aged 18-35 years or aged ≥ 65 years * Healthy without symptons of orthostatic intolerance (i.e., nausea, sweating, weakness, visual disturbance) * Seated systolic and/or diastolic BP \<140/90 mmHg; * Body mass index \<35 kg/m2 * Recreationally active (≤ 2 days of structured physical activity) * Regular menstrual cycles in young females Exclusion Criteria: * People diagnosed with cardiovascular, diabetes, inflammatory or renal diseases and neurodegenerative-related dementia * Tobacco users * People prescribed with beta-blockers * Pregnant females * People unable to fit or get into the lower body negative pressure chamber

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Conditions

The condition(s) this trial relates to.

Orthostatic Intolerance postural orthostatic tachycardia syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Orthostatic intolerance

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Massachusetts Boston

    RECRUITING

    Boston, Massachusetts, 02125, United States

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