Heart scan study tests if new drug reduces dangerous protein buildup
NCT ID NCT06073574
Summary
This study uses heart MRI scans to measure changes in amyloid protein buildup in patients with ATTR-CM, a serious heart condition. It involves up to 150 participants who are already enrolled in a larger trial testing an experimental drug called ION-682884 against a placebo. The goal is to see if the drug reduces the amount of harmful protein deposits in heart tissue over time compared to no treatment.
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Contacts and locations
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Locations
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Azienda Ospedale Università di Padova
Padua, 35128, Italy
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Azienda Ospedaliero - Universitaria Careggi
Florence, 50139, Italy
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Hospital Universitario Puerta de Hierro
Majadahonda, 28222, Spain
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Richmond Pharmacology
London, SE1 1YR, United Kingdom
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Royal Free London NHS Foundation Trust
London, NW3 2QG, United Kingdom
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Synexus - Manchester Clinical Research Centre
Manchester, M15 6SE, United Kingdom
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Synexus - Scotland Clinical Research Centre
Bellshill, ML4 3NJ, United Kingdom
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Synexus - Wales
Cardiff, CF15 9SS, United Kingdom
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Synexus Midlands Clinical Research Centre
Birmingham, B15 2SQ, United Kingdom
Conditions
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