Can a new drug shrink deadly protein clogs in the heart?
NCT ID NCT06073574
Summary
This study uses heart MRI scans to see if an experimental drug called ION-682884 can reduce the buildup of a harmful protein (amyloid) in the heart muscle. It involves up to 150 people who already have a heart condition caused by this protein buildup, known as ATTR-CM. The goal is to measure changes in the amount of this protein over time to see if the drug is working.
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Contacts and locations
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Locations
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Azienda Ospedale Università di Padova
Padua, 35128, Italy
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Azienda Ospedaliero - Universitaria Careggi
Florence, 50139, Italy
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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Hospital Universitario Puerta de Hierro
Majadahonda, 28222, Spain
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Oregon Health and Science University
Portland, Oregon, 97239, United States
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Richmond Pharmacology
London, SE1 1YR, United Kingdom
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Royal Free London NHS Foundation Trust
London, NW3 2QG, United Kingdom
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Synexus - Manchester Clinical Research Centre
Manchester, M15 6SE, United Kingdom
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Synexus - Scotland Clinical Research Centre
Bellshill, ML4 3NJ, United Kingdom
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Synexus - Wales
Cardiff, CF15 9SS, United Kingdom
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Synexus Midlands Clinical Research Centre
Birmingham, B15 2SQ, United Kingdom
Conditions
Explore the condition pages connected to this study.