Squeeze your way to better brain health? new study tests handgrip training

NCT ID NCT07223645

Knowledge-focused Sponsor: Florida State University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether doing handgrip exercises three times a week for eight weeks can improve blood vessel function in the brains of physically inactive adults aged 18 to 35. Researchers will measure brain blood flow using ultrasound and check blood pressure. The goal is to see if this simple, low-cost exercise can boost brain vascular health.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: Handgrip training device
What this could lead to: If it works, this could point toward a simple exercise to improve brain blood flow and lower blood pressure.
What could go wrong: This is a small, early-stage study (40 people) looking at short-term changes in blood flow, not long-term health outcomes. Results may not apply to older or less healthy people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 to 35 years old * Body mass index ≤30 kg/m2 (without obesity) * Physically inactive (not meeting the current recommendations of ≥150 minutes per week of moderate-to-vigorous aerobic exercise and not ≥2 days per week of resistance training) in last 6 months * Have a smartphone and are willing to download mobile applications used in this project Exclusion Criteria: * Having an overt chronic condition (e.g., cardiovascular, cerebrovascular, etc.) * Being pregnant, planning to become pregnant, or breastfeeding/lactating * Regular use of nicotine products in the past 6 months * Recent head injury/trauma or concussion

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inactivity/low levels of exercise

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Squeeze your way to better brain health? new study tests handgrip training

What the study statuses mean