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New combo therapy shows promise for stroke hand recovery

NCT ID NCT05736653

Disease control Sponsor: University of Utah Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether combining brain stimulation, nerve stimulation, and hand exercises can help people with chronic stroke regain hand movement. Fifty-one participants who had a stroke at least six months prior received the combined therapy. The goal was to see if it strengthens the connection between the brain and weak hand muscles, and improves hand function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Combined brain, nerve, and hand stimulation (transcranial magnetic stimulation, peripheral nerve stimulation, and functional electrical stimulation)
What this could lead to
If it works, this could point toward a new therapy to improve hand function in people with chronic stroke.
What could go wrong
This is a small, early-stage study (51 people) with no control group, so results may not apply to everyone. The improvements seen may be modest or not last long.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

51 people

The number who actually took part.

Started

Jun 2023

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 18-85 years 2. Diagnosis of first-ever subcortical stroke (single cerebrovascular accident) 3. Stroke onset of at least six months prior to the time of participation 4. A score of at least 1 out of 2 on the spherical grasping item of the Fugl-Meyer Upper Extremity Subscale to allow participants to grasp the ball 5. Cognitive skills to actively participate, as indicated by scores of \> 23 on the Mini-Mental Status Examination 6. English speaking Exclusion Criteria: 1. Inability to elicit a motor evoked potential (MEP) in the EDC muscle even with a 20% background muscle contraction 2. Presence of severe aphasia 3. Excessive spasticity of the wrist and finger muscles, defined as a Modified Ashworth Score \>2 4. Diagnosis of neurological disorders other than stroke 5. History of seizure or epilepsy 6. Orthopedic/musculoskeletal conditions (e.g., arthritis) affecting the upper extremity 7. Presence of metallic implants in the head or neck 8. Currently or planning to become pregnant 9. Difficulty maintaining alertness or remaining still 10. Ferromagnetic metallic implants, pacemakers, other implanted devices, or ventilators for magnetic resonance imaging (MRI) 11. Bodyweight \> 300 lbs due to MRI scanner dimensions (for subjects also undergoing MRI) 12. Psychiatric diagnosis according to the criteria of the Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-V), or who are on psychotropic medication 13. Life expectancy less than the duration of the study 14. Excessive pain in the paretic hand, defined as a Visual Analog Scale Score \>4 15. Participation in concurrent occupational therapy 16. Current use of recreational drugs and stimulants like cocaine and methylenedioxymethamphetamine (MDMA)

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Conditions

The condition(s) this trial relates to.

stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stroke

Contacts and locations

Locations

  • Neural Plasticity Rehabilitation and Movement Dynamics Lab

    Salt Lake City, Utah, 84108, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.