Can intensive therapy boost motor skills in kids with SMA?
NCT ID NCT07223320
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tests whether combining intensive hand-arm and leg therapy with strength training can improve motor function in children with spinal muscular atrophy (SMA). Five children will attend one 6-hour session each weekend for 15 weeks. Researchers will check if the therapy is feasible and measure changes in motor skills.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) plus functional strength training (FST)
- What this could lead to
- If this therapy works, it could offer a new way to improve motor skills and strength in children with SMA, complementing existing disease-modifying treatments.
- What could go wrong
- This is a very small pilot study with only 5 participants and no control group, so results may not apply to all children with SMA. The therapy is also time-intensive (90 hours over 15 weeks), which may be hard for families to maintain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 5 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Oct 2025
- Expected to finish
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Jul 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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5 to 17 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of SMA * Able to participate in all pre and post intervention assessments * Able to understand and speak English * Able to understand directions (no significant cognitive delay or serious behavioral issues that would limit participation) * Receiving a stable dose of disease-modifying therapies for at least 6 months prior to enrollment. Exclusion Criteria: * Orthopedic surgery within the last year (confound) * Initiation of any new pharmaceutical treatment during the study period * Participation in a clinical trial of an investigational therapy
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Center for Cerebral Palsy Research, Teachers College, Columbia University
New York, New York, 10027, United States
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