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Gut germs could influence heart healing after attack

NCT ID NCT07175181

Knowledge-focused Sponsor: Assiut University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at whether the bacteria in your gut can affect how your heart heals after a heart attack procedure called PCI. Researchers will measure a substance called TMAO, made by gut bacteria, in 144 patients. The goal is to see if TMAO levels are linked to changes in heart structure and function over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward dietary or probiotic strategies to improve heart recovery after a heart attack.
What could go wrong
This is an observational study, not a treatment trial. It may find no clear link between gut bacteria and heart remodeling, and results may not lead to direct patient benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 144 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2025

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Confirmed diagnosis of ST-elevation myocardial infarction (STEMI) and indication for PCI based on clinical guidelines.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years . * Confirmed diagnosis of ST-elevation myocardial infarction (STEMI) and indication for PCI based on clinical guidelines. * Patients scheduled to undergo primary PCI for STEMI. * Ability and willingness to provide informed consent for participation and for the collection of stool samples. * No significant comorbidities that may confound the results (e.g., chronic kidney disease, liver cirrhosis). * No prior use of antibiotics, probiotics, or prebiotics within the last 3 months, as these may significantly alter gut microbiota composition. * Willingness and ability to complete follow-up assessments as required by the study protocol. * Absence of major gastrointestinal disorders (e.g., inflammatory bowel disease, gastrointestinal infections) that could affect gut microbiota. Exclusion Criteria: * Age \< 18 years. * Chronic Diseases: * Chronic kidney disease (stage 3 or higher). * Chronic liver disease (e.g., cirrhosis). * Active malignancies. * Acute infections or active inflammatory conditions at the time of PCI. * Gastrointestinal Disorders: * Inflammatory bowel disease. * Celiac disease. * Diverticulitis. * Recent use of antibiotics, probiotics, or prebiotics within the last 3 months. * Use of immunosuppressive medications or chemotherapy. * Uncontrolled diabetes or hypertension.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Primary percutaneous coronary intervention

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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