Could a daily supplement boost your gut health? new study seeks answers
NCT ID NCT07618000
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a dietary supplement called PI-YSP-0111 in 140 healthy adults aged 18 to 65. Participants take either a high or low dose of the supplement or a placebo daily for 8 weeks. Researchers will measure changes in gut bacteria, body composition, and liver health markers to see if the supplement has any benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PI-YSP-0111 formulation (a dietary supplement containing probiotics, grape seed extract, oligo, and wolfberry extract)
- What this could lead to
- If it works, this could show that the supplement improves gut bacteria balance and liver health markers in healthy people.
- What could go wrong
- This is an early-stage study with no disease focus, so results may be small or not apply to the general population. Dietary supplements often show limited effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 140 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2026
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Healthy males or females aged 18 to 65 years. 2. BMI between 23.0 and 40.0 kg/m². 3. Waist circumference: ≥ 90 cm for males and ≥ 80 cm for females. 4. Participants are willing to maintain their usual dietary habits, daily routines, and physical activity levels during the study period, and have no plans to relocate. 5. Participants have fully understood the study procedures and have signed the informed consent form. Exclusion Criteria: 1. Presence of gastrointestinal diseases, such as inflammatory bowel disease, irritable bowel syndrome, gastroesophageal reflux disease, Crohn's disease, or a history of bariatric surgery. 2. Recent history of acute gastroenteritis, constipation or diarrhea; psychiatric disorders (e.g., depression or schizophrenia); cardiovascular diseases (e.g., hypertension); known allergy or hypersensitivity to the investigational product; extreme dietary habits; significant body weight change (\>4.5 kg) within the past three months; recent use of antibiotics or antifungal agents; or use of medications affecting gastrointestinal function (such as probiotics, laxatives, or nonsteroidal anti-inflammatory drugs \[NSAIDs\]). 3. Exposure to unapproved medications, alcohol abuse, or substance abuse. 4. Female-specific conditions, including significant gastrointestinal symptoms during menstruation, irregular menstrual cycles, pregnancy, planned pregnancy, or breastfeeding (participants who become pregnant during the study period will also be excluded). 5. Short-term use of corticosteroids, nonsteroidal anti-inflammatory drugs, immunosuppressive agents, interferons, or immunomodulatory agents within the past one month. 6. Use of any weight-loss medications (including oral agents, injections, or traditional Chinese medicine) within the past three months. 7. Participation in any other interventional clinical study within the past one month. 8. History of cancer or current malignancy within the past two years, except for non-melanoma skin cancer. 9. Occurrence of major trauma or any surgical procedures within the past one month. 10. History of diabetic ketoacidosis.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Taipei Medical University
RECRUITINGTaipei, Taiwan, 110, Taiwan
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Taipei Municipal WanFang Hospital(Managed by Taipei Medical University)
RECRUITINGTaipei, Taiwan, 116, Taiwan
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