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Gallbladder removal may make gut bacteria more sensitive to colonoscopy prep

NCT ID NCT07439640

Knowledge-focused Sponsor: Tongji Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the laxatives used for colonoscopy preparation change the gut bacteria in people who have had their gallbladder removed. Researchers will compare 10 people with prior gallbladder removal to 10 people with an intact gallbladder. All participants will provide stool samples before and after colonoscopy, and at 1, 3, and 6 months later, to see if the gallbladder-removal group's gut bacteria take longer to recover.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult patients scheduled for colonoscopy at the Department of Gastroenterology, Tongji Hospital, Wuhan, China. Participants are recruited consecutively from the outpatient clinic and voluntarily enrolled after providing written informed consent. Two cohorts are defined based on history of cholecystectomy: individuals with prior cholecystectomy (gallbladder removal group) and individuals with an intact gallbladder (normal group). All participants undergo routine bowel preparation with PEG-based laxatives and provide stool samples longitudinally over a 6-month period. No experimental interventions are administered.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Scheduled to undergo colonoscopy with polyethylene glycol (PEG)-based bowel preparation. * For the gallbladder removal group: prior cholecystectomy performed at least 6 months before enrolment. * For the normal group: intact gallbladder (no history of cholecystectomy). * Willing and able to provide written informed consent. * Willing to collect and mail stool samples at five specified time points (baseline, first non-watery stool after colonoscopy, 1 month, 3 months, 6 months). Exclusion Criteria: * Contraindications to colonoscopy (e.g., severe cardiopulmonary insufficiency, acute gastrointestinal bleeding, severe coagulopathy). * Known intolerance or allergy to polyethylene glycol (PEG). * Use of antibiotics, probiotics, or prebiotics within 6 months prior to enrolment. * Pregnancy or breastfeeding. * Mental disorders or any condition that may compromise the ability to comply with study procedures. * Major organ diseases (e.g., liver cirrhosis, chronic kidney disease stage 4-5, uncontrolled diabetes mellitus). * Participation in another interventional clinical trial within the last 3 months.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cholecystectomy

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Department of Gastroenterology Tongji Hospital, Tongji Medical college, Huazhong University of Science and technology

    RECRUITING

    Wuhan, Hubei, 430030, China

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