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Can Platelet-Rich fibrin or laser therapy boost gummy smile surgery results?

NCT ID NCT07532161

Symptom relief Sponsor: Damascus University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding liquid platelet-rich fibrin or low-level laser therapy to standard lip repositioning surgery can speed healing, reduce pain and swelling, and prevent the gummy smile from returning. Twenty-two adults with a gummy smile due to a hyperactive upper lip will be randomly assigned to one of the two treatments. The goal is to see which approach leads to better wound healing and longer-lasting cosmetic results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liquid platelet-rich fibrin and low-level laser therapy
What this could lead to
If it works, this could point toward a better way to heal and maintain results after gummy smile surgery, reducing pain and swelling.
What could go wrong
This is a very small, early-phase trial with only 22 participants, so results may not apply to everyone. The treatments are adjunctive, not a cure, and relapse may still occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 22 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients of both genders. 2. Patients presenting with a gummy smile in the maxillary anterior region (more than 3 mm) due to upper lip hypermobility. 3. Age 18-50 years. 4. Systemically healthy individuals, classified as ASA physical status I or II according to the American Society of Anesthesiologists (ASA) classification; that is, patients without systemic disease or with mild, well-controlled systemic conditions. 5. Patients with good oral hygiene, defined as an O'Leary Plaque Index ≤ 40%. 6. No previous lip repositioning surgery. Exclusion Criteria: 1. Pregnancy and lactation. 2. Individuals with a previous history of receiving facial Botox or filler injections. 3. Systemic diseases or conditions that contraindicate the use of local anesthesia. 4. Any physical condition that impairs the ability to perform proper oral hygiene measures. 5. Patients who are smokers or alcohol consumers. 6. Inability or unwillingness to cooperate. 7. In adequate width of attached gingiva. 8. Vertical maxillary excess (moderate to severe) requiring orthognathic intervention. 9. Short upper lip 10. Gingival display primarily caused by altered passive eruption requiring crown lengthening.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gummy smile

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry, Damascus university , Syria.

    RECRUITING

    Damascus, Rif-dimashq Governorate, Syria

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