Can hyaluronic acid help grow back receding gums?
NCT ID NCT07520539
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding cross-linked hyaluronic acid through microneedling after gum surgery can improve gum thickness and cover exposed tooth roots better than microneedling alone. It involves 22 adults with a single gum recession and thin gums. Participants will receive gum surgery followed by microneedling with or without hyaluronic acid, and results will be checked at 6 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cross-linked hyaluronic acid
- What this could lead to
- If it works, this could offer a better way to treat gum recession, improving gum thickness and covering exposed tooth roots.
- What could go wrong
- This is a small, early-phase trial with only 22 participants, so results may not apply to everyone. The treatment involves surgery and microneedling, which carry risks like pain, swelling, or infection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 22 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1. Inclusion criteria * Adult (≥18 years) with Single RT1 gingival recession in esthetic zone. * Thin gingival biotype (≤ 1mm). * Systemically healthy patients. * Non- smoker patients. * Full-mouth bleeding on probing (BOP) and plaque indices (PI) scores ≤15%. * Willingness to comply with follow up and maintenance. 2. Exclusion criteria * RT2 or RT3 recessions or multiple adjacent recessions. * Previous mucogingival surgery at the test site. * Use of medications causing gingival enlargement. * Uncontrolled systemic disease. * Pregnancy or lactation. * Current smokers.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
The full official record for this study. This one lists no contact details, but it is the first place any would appear.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.